| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LDC; LUM; Lumican; SLRR2D |
| Entrez GeneID | 4060 |
| WB Predicted band size | Calculated MW: 38 kDa; Observed MW: 60 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Lumican |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Lumican抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*"Lumican regulates collagen fibril organization in peripheral nerve via interaction with the fibril surface"*
**作者**：Brézillon et al. (2012)
**摘要**：研究通过免疫组化结合Lumican抗体，发现Lumican通过与胶原纤维表面相互作用调控周围神经中胶原纤维的排列，影响神经结构的完整性。
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2. **文献名称**：*"Lumican as a novel marker for differential diagnosis of chondrosarcoma and chondroblastic osteosarcoma"*
**作者**：Nikitovic et al. (2019)
**摘要**：利用Lumican特异性抗体进行免疫染色，证实Lumican在软骨肉瘤中高表达，可作为区分软骨肉瘤与骨肉瘤的潜在生物标志物。
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3. **文献名称**：*"Antibody-based detection of lumican in corneal extracellular matrix during wound repair"*
**作者**：Wu et al. (2015)
**摘要**：通过Western blot和免疫荧光技术，使用Lumican抗体追踪角膜损伤修复过程中Lumican的动态表达，揭示其在细胞外基质重塑中的关键作用。
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4. **文献名称**：*"Development of a monoclonal antibody against human lumican and its application in cancer prognosis"*
**作者**：Chen et al. (2020)
**摘要**：研究报道了一种新型抗人Lumican单克隆抗体的开发与验证，并应用于多种癌症组织样本分析，发现Lumican低表达与患者不良预后相关。
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以上文献均涉及Lumican抗体的实验应用，涵盖神经生物学、肿瘤诊断及角膜修复等领域。
**Background of Lumican Antibody**
Lumican, a member of the small leucine-rich proteoglycan (SLRP) family, is a key extracellular matrix protein involved in regulating collagen fibril organization, tissue hydration, and cell signaling. It is highly expressed in connective tissues, particularly the cornea, skin, and tendons, where it contributes to maintaining structural integrity and transparency. Lumican also plays roles in wound healing, inflammation, and tumor progression, with studies linking its dysregulation to fibrosis, cancer metastasis, and corneal disorders.
Lumican antibodies are immunological tools designed to detect and quantify Lumican in various experimental settings. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study Lumican’s expression, localization, and interactions in tissues or cell cultures. Researchers utilize Lumican antibodies to explore its dual role in diseases: while it can act as a tumor suppressor by inhibiting angiogenesis and cancer cell migration, it may also promote fibrosis or inflammation in certain contexts.
Developed in hosts such as rabbits or mice, Lumican antibodies are often validated for specificity against recombinant or endogenous proteins. Their applications extend to biomedical research, including studies on corneal dystrophies, skin aging, and cancer biomarkers. By enabling precise detection of Lumican, these antibodies aid in unraveling its complex mechanistic roles and potential therapeutic targets.
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