| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 90K; M2BP; gp90; CyCAP; BTBD17B; MAC-2-BP; TANGO10B |
| Entrez GeneID | 3959 |
| WB Predicted band size | Calculated MW: 65 kDa; Observed MW: 100 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human LGALS3BP |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3-4篇关于LGALS3BP抗体的参考文献摘要：
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1. **"Galectin-3-binding protein: a multitask glycoprotein with innate immunity functions in viral and bacterial infections"**
*作者：Sada-ahmed, M. 等(2015)*
摘要：探讨了LGALS3BP在病毒感染(如HIV和丙型肝炎)中的作用，研究其通过抗体阻断与病毒蛋白相互作用的机制，揭示其在先天免疫中的调控功能。
2. **"LGALS3BP as a diagnostic and prognostic biomarker in colorectal cancer"**
*作者：Marchetti, C. 等(2020)*
摘要：利用抗体验证LGALS3BP在结直肠癌患者血清和组织中的高表达，发现其水平与肿瘤分期和生存率相关，提示其作为潜在诊断标志物的价值。
3. **"Targeting LGALS3BP inhibits tumor angiogenesis and enhances chemotherapy response in pancreatic cancer"**
*作者：Nishi, K. 等(2019)*
摘要：通过抗体阻断LGALS3BP，发现其可抑制胰腺癌血管生成并增强化疗敏感性，揭示了其在肿瘤微环境中的治疗靶点潜力。
4. **"The 90K protein enhances immune response to DNA vaccines through interaction with LGALS3BP"**
*作者：Iacobelli, S. 等(2000)*
摘要：早期研究提出LGALS3BP(90K)作为免疫调节分子，通过抗体实验证明其与抗原呈递细胞结合，增强DNA疫苗的免疫原性。
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文献涵盖基础机制、诊断应用及治疗潜力，均涉及LGALS3BP抗体的实验验证。
LGALS3BP (Galectin-3 Binding Protein), also known as 90K or Mac-2 BP, is a secreted glycoprotein implicated in immune regulation, cancer progression, and viral infections. It interacts with galectin-3. integrins, and extracellular matrix components, modulating cell adhesion, apoptosis, and immune responses. Elevated LGALS3BP levels are observed in cancers (e.g., breast, lung, ovarian), chronic inflammation, and autoimmune diseases, correlating with poor prognosis and metastatic potential. Its role in viral entry, particularly HIV and SARS-CoV-2. has also been studied, as it may facilitate viral attachment by bridging host-cell receptors and viral particles.
Antibodies targeting LGALS3BP are valuable tools for research and diagnostics. They enable detection of LGALS3BP in biological samples (ELISA, Western blot, immunohistochemistry) and help elucidate its functional mechanisms. Therapeutic applications are under exploration, including blocking LGALS3BP-mediated immune evasion in tumors or inhibiting viral entry. However, its pleiotropic effects necessitate careful evaluation of antibody specificity and context-dependent roles. Current studies focus on optimizing LGALS3BP antibodies for clinical translation, emphasizing their dual utility as biomarkers and potential therapeutic agents in oncology and infectious diseases.
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