| WB | 1/500-1/1000 | Rat |
| IF | 咨询技术 | Rat |
| IHC | 咨询技术 | Rat |
| ICC | 1/50-1/200 | Rat |
| FCM | 咨询技术 | Rat |
| Elisa | 咨询技术 | Rat |
| Aliases | Charcot-Leyden crystal protein 2; CLC2; Galectin-14; Gal-14 |
| Entrez GeneID | 56891 |
| WB Predicted band size | Calculated MW: 16 kDa; Observed MW: 16 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Rat |
| Immunogen | A synthetic peptide of human LGALS14 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于LGALS14抗体的3篇假设参考文献示例，基于galectin家族相关研究的典型方向整理而成。请注意，这些文献为示例性质，实际文献需通过学术数据库验证：
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1. **文献名称**: *"Bovine Galectin-14: A Critical Mediator of Maternal-Fetal Immune Tolerance in Ruminants"*
**作者**: Farmer, D., et al. (2015)
**摘要**: 研究牛Galectin-14在妊娠早期胎盘中的表达，开发了特异性多克隆抗体用于免疫组化分析，发现其定位在滋养层细胞中，并可能通过调节T细胞活性维持母胎免疫耐受。
2. **文献名称**: *"Anti-galectin-14 Antibodies Block Trophoblast Differentiation in Vitro"*
**作者**: Clark, G. F., et al. (2017)
**摘要**: 利用抗LGALS14抗体处理体外培养的滋养层细胞，发现抗体通过抑制Galectin-14与细胞表面糖蛋白的相互作用，导致细胞分化受阻，提示其在胎盘发育中的关键作用。
3. **文献名称**: *"LGALS14 as a Potential Biomarker for Preeclampsia: Validation via Antibody-Based Detection"*
**作者**: Roberts, J. K., et al. (2020)
**摘要**: 开发了一种基于抗LGALS14抗体的ELISA检测方法，发现子痫前期孕妇血清中Galectin-14水平显著降低，表明其可能作为妊娠并发症的早期诊断标志物。
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**备注**：
- 实际研究中，Galectin-14(LGALS14)的研究可能集中在反刍动物(如牛、羊)胎盘生物学领域，人类同源蛋白的研究较少。
- 建议通过PubMed或Google Scholar以关键词“LGALS14 antibody”“Galectin-14 immune function”等检索最新文献。
The LGALS14 antibody targets galectin-14 (Gal-14), a member of the galectin family of β-galactoside-binding proteins. Galectins play roles in immune regulation, cell adhesion, and inflammation. LGALS14. encoded by the *LGALS14* gene, is uniquely expressed in placental and reproductive tissues, particularly by trophoblasts during pregnancy. It is implicated in maternal-fetal immune tolerance, possibly by modulating interactions between placental cells and maternal immune components, thereby supporting pregnancy maintenance. Dysregulation of galectin-14 has been linked to pregnancy-related disorders like preeclampsia and preterm birth.
Antibodies against LGALS14 serve as critical tools for studying its expression, localization, and function. They enable detection of galectin-14 in tissue samples (e.g., via immunohistochemistry) or biological fluids (e.g., ELISA), aiding research into placental development and gestational pathologies. Additionally, LGALS14 antibodies have exploratory applications in cancer research, as galectins are often overexpressed in tumors and may influence immune evasion. Commercial LGALS14 antibodies are typically monoclonal or polyclonal, validated for specificity in Western blotting, immunofluorescence, or flow cytometry. Recent studies also investigate galectin-14's role in infection responses and autoimmune conditions, expanding its therapeutic relevance. However, standardized protocols for clinical use remain under development. Overall, LGALS14 antibodies are vital for deciphering galectin-14's biological and pathological mechanisms, with potential diagnostic and therapeutic implications.
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