| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LTA4; LTA4 hydrolase; LTA4H |
| Entrez GeneID | 4048 |
| WB Predicted band size | Calculated MW: 69 kDa; Observed MW: 69 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Leukotriene A4 hydrolase |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于 Leukotriene A4 Hydrolase (LTA4H) 抗体的3篇参考文献示例(内容为虚构，仅供格式参考)：
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1. **文献名称**: *Development of a Monoclonal Antibody Against Human LTA4H for Immunohistochemical Analysis*
**作者**: Smith J, et al.
**摘要**: 本研究报道了一种特异性识别人类LTA4H的单克隆抗体的开发与验证。该抗体在Western blot和免疫组化中表现出高特异性，成功用于检测多种炎症组织中LTA4H的表达水平，为研究其在炎症性疾病中的分布提供了工具。
2. **文献名称**: *LTA4H Inhibition via Neutralizing Antibody Attenuates Neutrophil Recruitment in Murine Arthritis Models*
**作者**: Chen L, et al.
**摘要**: 通过筛选获得的中和性抗体可阻断LTA4H的酶活性，显著降低LTB4的生成。在类风湿性关节炎小鼠模型中，该抗体减少了中性粒细胞浸润和关节炎症，提示其治疗慢性炎症疾病的潜力。
3. **文献名称**: *Structural Mapping of LTA4H Epitopes Using Phage Display-Derived Antibodies*
**作者**: Rodriguez M, et al.
**摘要**: 利用噬菌体展示技术筛选出靶向LTA4H特定表位的抗体，结合冷冻电镜分析揭示了抗体与酶活性位点的结合模式，为设计靶向LTA4H的抑制剂提供了结构基础。
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以上示例展示了LTA4H抗体在检测工具开发、治疗干预及结构研究中的应用。实际文献需通过PubMed或Web of Science等平台检索关键词(如“LTA4H antibody”“immunoassay”“therapeutic inhibition”)获取。
Leukotriene A4 hydrolase (LTA4H) is a bifunctional zinc metalloenzyme that plays a critical role in inflammatory processes by catalyzing the hydrolysis of leukotriene A4 (LTA4) to leukotriene B4 (LTB4), a potent chemoattractant and mediator of inflammation. LTA4H also exhibits aminopeptidase activity, though its physiological substrate remains unclear. This enzyme is expressed in various tissues, including immune cells, and its dysregulation has been linked to inflammatory diseases such as asthma, rheumatoid arthritis, and atherosclerosis.
Antibodies targeting LTA4H are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They enable detection via techniques like Western blotting, immunohistochemistry, and ELISA, aiding in research on inflammation mechanisms or drug development. Some antibodies are designed to recognize specific epitopes, such as the N-terminal domain or catalytic sites, to assess enzymatic activity or inhibition.
LTA4H antibodies (polyclonal or monoclonal, often raised in rabbits or mice) are also used to explore its dual enzymatic roles and interactions with signaling pathways. Recent studies highlight its potential as a therapeutic target, with antibodies helping validate inhibitors in preclinical models. However, cross-reactivity with homologous proteins or splice variants requires careful validation. Researchers must optimize antibody usage based on tissue type, species specificity, and experimental conditions to ensure reliable results.
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