| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RBMX; HNRPG; RBMXP1; RNA-binding motif protein; X chromosome; Glycoprotein p43; Heterogeneous nuclear ribonucleoprotein G; hnRNP G |
| Entrez GeneID | 27316 |
| WB Predicted band size | Calculated MW: 42 kDa; Observed MW: 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human hnRNP G |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于hnRNP G抗体的示例参考文献(注：以下内容为模拟示例，非真实文献)：
1. **文献名称**：*hnRNP G regulates mRNA splicing and stability in neuronal development*
**作者**：Chen X, et al.
**摘要**：本研究利用hnRNP G特异性抗体进行免疫沉淀和RNA测序，揭示了其在神经元发育中通过调控mRNA剪接和稳定性影响突触形成的关键作用。
2. **文献名称**：*Antibody-based profiling of hnRNP G reveals its interaction with the X chromosome inactivation machinery*
**作者**：Lee S, et al.
**摘要**：通过Western blot和免疫荧光技术，该研究证实hnRNP G抗体可特异性识别蛋白表达，并发现其与X染色体失活相关复合物(如XIST RNA)存在功能关联。
3. **文献名称**：*hnRNP G modulates androgen receptor signaling in prostate cancer via antibody-validated protein interactions*
**作者**：Gupta R, et al.
**摘要**：使用hnRNP G抗体进行免疫共沉淀和ChIP实验，证明其通过结合雄激素受体(AR)调控靶基因转录，影响前列腺癌细胞增殖。
4. **文献名称**：*Dysregulation of hnRNP G in autoimmune diseases: Insights from ELISA and tissue staining*
**作者**：Müller T, et al.
**摘要**：通过ELISA和免疫组化分析患者样本，发现系统性红斑狼疮患者血清中hnRNP G抗体水平升高，提示其可能参与自身免疫反应的病理机制。
如需真实文献，建议通过PubMed或Google Scholar搜索关键词“hnRNP G antibody”或结合具体研究场景(如“hnRNP G antibody splicing”)进一步筛选。
**Background of hnRNP G Antibody**
Heterogeneous nuclear ribonucleoprotein G (hnRNP G), a member of the hnRNP family, plays critical roles in RNA metabolism, including pre-mRNA splicing, transport, and stability. It contains an RNA recognition motif (RRM) and a unique arginine-rich domain, enabling interactions with RNA and other proteins. hnRNP G is notably involved in regulating alternative splicing events, such as those mediated by the TRA2β/SRSF3 splicing factor, impacting gene expression in development and disease.
Antibodies targeting hnRNP G are essential tools for studying its expression, localization, and functional mechanisms. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate hnRNP G's role in cellular processes. Research has linked hnRNP G dysregulation to various pathologies, including cancer (e.g., breast and lung cancers) and neurodegenerative disorders, where aberrant RNA processing contributes to disease progression.
hnRNP G antibodies also aid in exploring its interactions with spliceosome components and other hnRNP proteins, shedding light on its regulatory networks. Their application in clinical studies may help identify hnRNP G as a potential biomarker or therapeutic target. Available as monoclonal or polyclonal variants, these antibodies are validated for specificity and reproducibility, ensuring reliability in diverse experimental models.
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