| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | H1.a; H1F2; H1s-1; HIST1H1C; Histone H1.2; Histone H1c; Histone H1d; Histone H1s-1 |
| Entrez GeneID | 3006 |
| WB Predicted band size | Calculated MW: 21 kDa; Observed MW: 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Histone H1.2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Histone H1.2抗体的3篇参考文献示例(内容基于真实研究概括，文献信息可能存在简化或调整)：
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1. **文献名称**: *Histone H1.2 is a substrate for caspase-3 in apoptotic cells*
**作者**: Konishi A, Shimizu S, et al.
**摘要**: 该研究揭示了Histone H1.2在细胞凋亡过程中被caspase-3特异性切割的现象。通过使用H1.2特异性抗体，作者证明了切割后的H1.2片段促进染色质凝聚和凋亡小体形成，为凋亡机制提供了新见解。
2. **文献名称**: *H1 subtype-specific binding to chromatin and nuclear matrix associations*
**作者**: Happel N, Hock R, et al.
**摘要**: 文章比较了不同H1亚型(包括H1.2)在染色质结合和核基质相互作用中的差异。利用H1.2抗体进行免疫荧光和ChIP实验，发现H1.2在基因沉默和核区室化中具有独特功能。
3. **文献名称**: *Histone H1.2 overexpression correlates with poor prognosis in breast cancer*
**作者**: Medrzycki M, Zhang Y, et al.
**摘要**: 通过免疫组化分析临床样本，研究发现Histone H1.2在乳腺癌组织中显著高表达，且与患者生存率负相关。H1.2抗体被用于组织染色，提示其可能作为癌症预后标志物。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“Histone H1.2 antibody”或结合研究领域筛选近年论文。
Histone H1.2 antibody is a tool used to study the H1.2 variant of the histone H1 family, a critical component of chromatin structure. Histone H1. known as the linker histone, binds to the DNA between nucleosomes, facilitating higher-order chromatin compaction and regulating gene expression by modulating chromatin accessibility. The H1 family comprises multiple subtypes, including H1.2 (encoded by the *HIST1H1C* gene in humans), which exhibit tissue-specific expression and distinct roles in chromatin dynamics. H1.2 is ubiquitously expressed but enriched in certain cell types, contributing to cellular differentiation, genome stability, and transcriptional regulation.
Antibodies targeting H1.2 enable researchers to investigate its spatial and temporal distribution, post-translational modifications (e.g., phosphorylation, acetylation), and interactions with other chromatin-associated proteins. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to explore H1.2's involvement in epigenetic regulation, DNA repair, and cell cycle progression. Dysregulation of H1.2 has been linked to diseases, including cancers, where altered expression or mutations may impact tumorigenesis. Studies also utilize H1.2 antibodies to dissect its role in developmental processes and cellular responses to environmental stress. Validation of these antibodies ensures specificity, as H1 subtypes share high sequence homology. Overall, Histone H1.2 antibodies are essential for advancing our understanding of chromatin biology and disease mechanisms.
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