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Rabbit Monoclonal HCE Antibody

  • 中文名： HCE抗体
  • 别    名： HCE; HCE1; hCAP; CAP1A
货号: IPDX21481
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHCE; HCE1; hCAP; CAP1A
Entrez GeneID8732
WB Predicted band sizeCalculated MW: 69 kDa; Observed MW: 69 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenRecombinant protein of human HCE
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是模拟生成的关于HCE抗体的参考文献示例(非真实文献，仅供格式参考)：

1. **《Human Corneal Epithelial Antibody Profiling in Dry Eye Syndrome》**

- 作者：Smith J, et al.

- 摘要：研究通过ELISA和免疫荧光技术分析干眼症患者HCE抗体表达水平，发现IgA类抗体与炎症程度呈正相关，提示其在疾病诊断中的潜在价值。

2. **《HCE-Specific Autoantibodies in Ocular Surface Disorders》**

- 作者：Wang L, Zhang Y.

- 摘要：探讨HCE抗体在自身免疫性眼表疾病中的病理机制，证实抗HCE IgG抗体可触发角膜上皮细胞凋亡，为靶向治疗提供依据。

3. **《Novel Biomarker Discovery: HCE Antibody in Tear Fluid Analysis》**

- 作者：Tanaka K, et al.

- 摘要：开发基于微流控芯片的泪液HCE抗体检测方法，发现其浓度与角膜损伤修复速度相关，提出无创监测角膜病变的新策略。

4. **《Cross-Reactivity of HCE Antibodies with Microbial Antigens》**

- 作者：Garcia R, et al.

- 摘要：揭示部分HCE抗体与金黄色葡萄球菌抗原存在交叉反应，暗示感染后免疫应答可能参与角膜炎症的分子模拟机制。

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注：以上为虚构示例，实际文献需通过PubMed、Web of Science或Google Scholar以关键词“HCE antibody”“corneal epithelial autoantibody”等检索。

背景信息

Human carboxylesterase (HCE) antibodies are immunological tools designed to target carboxylesterase enzymes, primarily CES1 and CES2. which play critical roles in drug metabolism, lipid processing, and detoxification. These enzymes hydrolyze ester-containing compounds, including prodrugs (e.g., antivirals, chemotherapeutics) and environmental toxins, influencing pharmacokinetics and therapeutic efficacy. HCE antibodies are widely used in biomedical research to study enzyme expression, localization, and activity in tissues like the liver, intestines, and macrophages, where these enzymes are highly expressed. Dysregulation of HCEs has been linked to drug resistance, metabolic disorders, and neurodegenerative diseases, making these antibodies valuable for investigating disease mechanisms. They are employed in techniques such as Western blotting, immunohistochemistry, and ELISA to assess protein levels in clinical samples or experimental models. Recent studies also explore HCEs as biomarkers for cancer prognosis or targets for enzyme-activated therapeutics. However, challenges persist in ensuring antibody specificity due to structural similarities among HCE isoforms. Advances in recombinant protein technology and epitope mapping have improved antibody validation, supporting their utility in pharmacology, toxicology, and translational research aimed at personalized medicine strategies.

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