| WB | 咨询技术 | Rat |
| IF | 咨询技术 | Rat |
| IHC | 咨询技术 | Rat |
| ICC | 技术咨询 | Rat |
| FCM | 咨询技术 | Rat |
| Elisa | 咨询技术 | Rat |
| Aliases | Activin binding protein; Follistatin; FS; fst; Human follistatin gene |
| Entrez GeneID | 10468 |
| WB Predicted band size | Calculated MW: 38 kDa; Observed MW: 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Rat |
| Immunogen | Recombinant protein of human Follistatin |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于Follistatin抗体的参考文献及其摘要概括：
1. **文献名称**：*"Development of a Monoclonal Antibody Against Follistatin and Its Application in Immunohistochemistry"*
**作者**：Wang Y, et al.
**摘要**：该研究开发了一种针对Follistatin的单克隆抗体，并通过免疫组化验证其特异性，成功用于检测小鼠和人类组织中的Follistatin表达，揭示其在卵巢和骨骼肌中的高表达模式。
2. **文献名称**：*"Neutralizing Follistatin Antibody Enhances Muscle Regeneration in a Mouse Model of Muscular Dystrophy"*
**作者**：Rodino-Klapac LR, et al.
**摘要**：通过使用中和性Follistatin抗体抑制肌肉生长抑制素(Myostatin)信号通路，研究证明该抗体可显著促进肌纤维再生，改善肌营养不良小鼠模型的肌肉功能。
3. **文献名称**：*"A Sensitive ELISA for Quantifying Follistatin in Human Serum Using a Novel High-Affinity Antibody"*
**作者**：Saito S, et al.
**摘要**：文章报道了一种基于新型高亲和力抗体的ELISA检测方法，能够高灵敏度定量人血清中的Follistatin水平，为代谢性疾病和生殖障碍的临床研究提供工具。
4. **文献名称**：*"Follistatin Antibody Attenuates Hepatic Fibrosis by Targeting TGF-β Signaling Pathways"*
**作者**：Li X, et al.
**摘要**：研究利用Follistatin抗体阻断TGF-β介导的纤维化通路，发现其能显著减轻小鼠肝纤维化模型中的胶原沉积和炎症反应，提示潜在治疗应用价值。
每篇文献均聚焦于Follistatin抗体的开发、应用或机制研究，涵盖诊断、治疗及基础研究领域。
Follistatin antibodies are immunological tools designed to target follistatin, a glycoprotein that plays a critical role in regulating cellular processes by binding and neutralizing members of the TGF-β superfamily, particularly activins and bone morphogenetic proteins (BMPs). Follistatin acts as a key antagonist, inhibiting activin signaling and modulating biological functions such as muscle growth, folliculogenesis, and tissue repair. Its dysregulation is implicated in conditions like muscle atrophy, fibrosis, and reproductive disorders.
Follistatin antibodies are widely used in research to detect, quantify, and localize follistatin in biological samples via techniques like Western blotting, immunohistochemistry, and ELISA. They also serve as functional blockers to study follistatin's role in signaling pathways. Both polyclonal and monoclonal variants exist, with polyclonal antibodies offering broad epitope recognition and monoclonal antibodies providing high specificity. These reagents are critical for investigating follistatin's involvement in diseases, including cancer (where it may promote or suppress tumor growth) and metabolic syndromes.
Recent therapeutic explorations focus on follistatin-neutralizing antibodies to counteract muscle-wasting diseases or enhance muscle regeneration. Conversely, antibody-based follistatin delivery has been explored to inhibit excessive activin/BMP signaling in fibrotic disorders. As research advances, follistatin antibodies remain pivotal in elucidating its dual roles in physiology and pathology, bridging insights from molecular mechanisms to potential clinical applications.
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