首页 / 产品 / 抗体 / 一抗

Rabbit Monoclonal FNTA Antibody

  • 中文名： FNTA抗体
  • 别    名： FPTA; PTAR2; PGGT1A
货号: IPDX21400
Price： ￥1280
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesFPTA; PTAR2; PGGT1A
Entrez GeneID2339
WB Predicted band sizeCalculated MW: 44 kDa; Observed MW: 44 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenA synthetic peptide of human FNTA
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

+ +

参考文献

以下是关于FNTA抗体的3篇参考文献及其摘要概括：

1. **文献名称**：*Farnesyltransferase alpha subunit knockdown alters endothelial cell morphology and motility*

**作者**：Chen Z, et al.

**摘要**：研究利用FNTA特异性抗体验证siRNA敲低效果，发现抑制FNTA表达会破坏血管内皮细胞迁移和微管结构，提示其在细胞骨架调控中的作用。

2. **文献名称**：*Development of a monoclonal antibody targeting farnesyltransferase alpha for cancer biomarker detection*

**作者**：Kimura T, et al.

**摘要**：报道了一种新型FNTA单克隆抗体的开发，验证其在高通量ELISA和免疫组化中的应用，显示其在多种癌症组织中高表达，可能作为治疗靶点。

3. **文献名称**：*Role of farnesyltransferase in Hutchinson-Gilford progeria syndrome: Insights from antibody-based inhibition studies*

**作者**：Gordon LB, et al.

**摘要**：通过FNTA抗体阻断法尼基转移酶活性，发现抑制FNTA可减少早衰症相关异常蛋白的积累，为靶向治疗提供实验依据。

注：以上文献信息为模拟示例，实际文献需通过PubMed或学术数据库检索确认。

背景信息

The FNTA antibody targets the alpha subunit of farnesyltransferase (FNTA), a critical enzyme in the Ras signaling pathway. Farnesyltransferase, composed of FNTA and FNTB subunits, catalyzes the post-translational farnesylation of proteins—a lipid modification essential for membrane localization and activation of key signaling molecules like Ras, Rheb, and lamins. This process is vital for cellular functions, including proliferation, differentiation, and survival. Dysregulation of farnesyltransferase activity is implicated in cancers, neurodegenerative disorders (e.g., Hutchinson-Gilford progeria), and viral infections (e.g., hepatitis D virus replication). FNTA antibodies are widely used in research to study protein farnesylation dynamics, enzyme expression levels, and therapeutic responses to farnesyltransferase inhibitors (FTIs), which are explored as anticancer agents. These antibodies enable techniques such as Western blotting, immunohistochemistry, and immunoprecipitation, aiding in the identification of FNTA in cellular and tissue contexts. Studies using FNTA antibodies have also clarified its structural role in the enzyme complex and its interactions with substrates or inhibitors. By detecting FNTA expression changes under pathological conditions or pharmacological interventions, these tools contribute to understanding disease mechanisms and developing targeted therapies.

客户数据及评论

折叠内容

大包装询价

×