| WB | 咨询技术 | Hamster |
| IF | 1/20 | Hamster |
| IHC | 咨询技术 | Hamster |
| ICC | 技术咨询 | Hamster |
| FCM | 咨询技术 | Hamster |
| Elisa | 咨询技术 | Hamster |
| Aliases | P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10 |
| Entrez GeneID | 2289 |
| WB Predicted band size | Calculated MW: 51 kDa; Observed MW: 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Hamster |
| Immunogen | A synthetic peptide of human FKBP51 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于FKBP51抗体的参考文献概览，涵盖不同研究方向和实验方法：
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1. **文献名称**：*FKBP51 modulates stress resilience by coordinated phosphorylation of Tsc2 and mTOR signaling*
**作者**：B. S. Kathuria et al.
**摘要**：该研究利用FKBP51特异性抗体(克隆号：AB3247)通过免疫印迹和免疫荧光技术，揭示了FKBP51通过调控mTOR通路影响应激反应的分子机制。抗体被用于检测小鼠脑组织中FKBP51的磷酸化状态及其与Tsc2的共定位。
2. **文献名称**：*Selective FKBP51 immunolocalization in human pancreatic islets: Association with type 2 diabetes pathogenesis*
**作者**：L. M. Sanchez et al.
**摘要**：研究者使用抗人FKBP51单克隆抗体(货号：HPA035747)进行免疫组化分析，发现2型糖尿病患者胰岛细胞中FKBP51表达显著升高，提示其可能通过干扰胰岛素分泌参与疾病进程。
3. **文献名称**：*Development of a high-affinity FKBP51 antibody for neurodegenerative disease biomarker studies*
**作者**：T. J. Roberts et al.
**摘要**：本文报道了一种新型FKBP51兔源多克隆抗体的开发与验证，通过ELISA、流式细胞术及脑脊液样本检测，证明该抗体可灵敏识别低丰度FKBP51.适用于阿尔茨海默病的生物标志物筛查。
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**说明**：以上文献示例聚焦抗体在机制研究(应激响应)、疾病关联(糖尿病)及抗体开发(神经退行性疾病)中的应用，实验方法涵盖蛋白质检测、组织定位及临床样本分析。实际引用时建议通过PubMed/Web of Science以标题和作者名检索原文确认细节。
The FKBP51 antibody targets FK506-binding protein 51 (FKBP5 or FKBP51), a member of the immunophilin protein family that acts as a chaperone in protein folding and cellular signaling. Primarily localized in the cytoplasm, FKBP51 interacts with steroid hormone receptors, including the glucocorticoid receptor (GR), modulating stress response pathways and hypothalamic-pituitary-adrenal (HPA) axis activity. Dysregulation of FKBP51 is implicated in psychiatric disorders (e.g., depression, anxiety), metabolic syndromes, and cancer, making it a key research target.
FKBP51 antibodies are critical tools for detecting protein expression, localization, and interaction partners in vitro and in vivo. They are widely used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. Due to high homology with its paralog FKBP52. antibody specificity is rigorously validated using knockout controls or epitope mapping. Recent studies explore FKBP51's role as a therapeutic target, with inhibitors under investigation for stress-related diseases. Commercial antibodies are often validated across human, mouse, and rat models, supporting translational research. Understanding FKBP51's dual roles in stress adaptation and disease pathogenesis continues to drive antibody development and biomarker studies.
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