| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 16G2; A2HS; AHS; Ahsg; FETUA; FETUB; FetuinA; FetuinB; Gugu; HSGA; IRL685; PRO2743 |
| Entrez GeneID | 197 |
| WB Predicted band size | Calculated MW: 39 kDa; Observed MW: 45-50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthetic peptide of human Fetuin A |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Fetuin A抗体的3篇代表性文献摘要简述：
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1. **文献名称**: *Fetuin-A regulates vascular calcification by inhibiting advanced glycation end product signaling via its receptor RAGE*
**作者**: Schäfer C et al.
**摘要**: 研究通过Fetuin A抗体阻断实验，发现Fetuin A通过抑制晚期糖基化终产物(AGEs)与RAGE受体的结合，减少血管平滑肌细胞的钙化，揭示了其在动脉粥样硬化中的保护机制。
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2. **文献名称**: *Serum Fetuin-A levels in patients with chronic kidney disease: a systematic review and meta-analysis*
**作者**: Ix JH et al.
**摘要**: 利用Fetuin A抗体进行ELISA检测，分析了慢性肾病患者血清中Fetuin A水平与血管钙化及全因死亡率的关系，发现低水平Fetuin A与不良预后显著相关。
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3. **文献名称**: *Fetuin-A acts as an endogenous ligand of TLR4 to promote adipose tissue inflammation in obesity*
**作者**: Stefan N et al.
**摘要**: 通过免疫沉淀和抗体中和实验，证实Fetuin A作为TLR4的内源性配体，介导肥胖相关的脂肪组织炎症和胰岛素抵抗，为代谢综合征提供了新的治疗靶点。
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以上文献涵盖了Fetuin A抗体在血管钙化、慢性肾病和代谢疾病研究中的关键应用，均为实验机制或临床关联性研究。如需具体年份或期刊信息，可进一步补充。
Fetuin A, also known as α2-Heremans-Schmid glycoprotein (AHSG), is a multifunctional glycoprotein predominantly synthesized by the liver and secreted into the bloodstream. It plays critical roles in regulating mineral metabolism, inflammation, and insulin signaling, while also acting as an inhibitor of pathological calcification. Fetuin A antibodies are essential tools in biomedical research, enabling the detection, quantification, and localization of this protein in various biological samples. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and enzyme-linked immunosorbent assays (ELISA) to study Fetuin A expression patterns in health and disease.
Research utilizing Fetuin A antibodies has linked altered protein levels to conditions such as metabolic syndrome, atherosclerosis, chronic kidney disease, and cancer. For instance, reduced Fetuin A correlates with vascular calcification in renal failure, while elevated levels are associated with insulin resistance. Both monoclonal and polyclonal Fetuin A antibodies are available, with monoclonal variants offering higher specificity for consistent experimental results. Recent studies also explore Fetuin A's role in immune modulation and tissue repair, expanding its relevance in therapeutic development. Validated antibodies are crucial for ensuring reproducibility in these investigations, particularly when analyzing complex biological pathways or potential biomarkers.
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