| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | C3 binding protein; C3b/C4b receptor; C3BR; C4BR; CD35; CR1; KN |
| Entrez GeneID | 1378 |
| WB Predicted band size | Calculated MW: 224 kDa; Observed MW: 280 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human CD35 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于CD35抗体的3篇模拟参考文献示例(非真实文献，供格式参考)：
1. **标题**: "CD35 Expression in Autoimmune Diseases: A Potential Biomarker for Lupus Activity"
**作者**: Smith A, et al.
**摘要**: 研究分析了CD35在系统性红斑狼疮(SLE)患者外周血细胞中的表达水平，发现其与疾病活动度呈负相关，提示CD35可能作为SLE的潜在治疗靶点。
2. **标题**: "Structural Characterization of Anti-CD35 Monoclonal Antibodies for Complement Regulation"
**作者**: Brown C, et al.
**摘要**: 通过X射线晶体学解析了CD35抗体与补体受体1(CR1)的结合表位，揭示了其抑制补体过度激活的分子机制，为开发免疫调节药物提供依据。
3. **标题**: "Anti-CD35 Antibody Enhances Clearance of Pathogenic Immune Complexes in Murine Models"
**作者**: Zhang L, et al.
**摘要**: 在小鼠模型中验证了CD35抗体通过促进肝脾巨噬细胞对免疫复合物的吞噬作用，改善实验性血管炎症状，支持其在免疫复合物相关疾病中的应用潜力。
**提示**：以上为模拟示例，实际文献请通过PubMed、Google Scholar等平台以“CD35 antibody”或“CR1 (CD35)”为关键词检索。
CD35. also known as complement receptor type 1 (CR1), is a transmembrane glycoprotein encoded by the *CR1* gene in humans (chromosome 1q32). It primarily functions in the immune system by binding complement components C3b and C4b, facilitating phagocytosis of opsonized pathogens and clearance of immune complexes. CD35 is expressed on erythrocytes, leukocytes, and follicular dendritic cells, playing roles in immune regulation and antigen presentation.
CD35-specific antibodies are valuable tools for studying its expression, distribution, and function. Monoclonal antibodies targeting CD35 (e.g., clones E11. J3D3) are widely used in flow cytometry, immunohistochemistry, and immunoassays to identify cell subtypes or assess CR1-related pathologies. In research, these antibodies help elucidate CD35's involvement in diseases like autoimmune disorders, infections, and cancers, where altered CR1 expression correlates with disease progression.
Therapeutically, CD35 antibodies have been explored for targeting immune complexes in conditions like lupus or enhancing complement-mediated tumor cell lysis. However, clinical applications remain limited, partly due to CR1's complex splice variants and tissue-specific roles. Recent studies also investigate CD35 as a biomarker for immune dysregulation. Overall, CD35 antibodies continue to advance both basic and translational research in immunology and hematology.
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