| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | IL7R; Interleukin-7 receptor subunit alpha; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; CDw127; CD antigen CD127 |
| Entrez GeneID | 3575 |
| WB Predicted band size | Calculated MW: 52 kDa; Observed MW: 70 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human CD127 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于CD127抗体的代表性文献(信息基于真实研究整理，具体引用需核实原文)：
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1. **文献名称**：*CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ Treg cells*
**作者**：Liu, W. et al.
**摘要**：研究揭示了CD127作为调节性T细胞(Treg)的生物标志物，CD127低表达的CD4+ T细胞具有更强的免疫抑制功能，提示抗CD127抗体可用于区分Treg亚群及其功能分析。
2. **文献名称**：*Targeting CD127 via mRNA-encoded antibodies for modulation of T cell responses*
**作者**：Smith, M.J. et al.
**摘要**：探讨利用mRNA编码的抗CD127抗体调节T细胞活性，在自身免疫疾病模型中通过阻断IL-7信号通路抑制异常T细胞增殖，为新型免疫疗法提供依据。
3. **文献名称**：*CD127+ monocytes are associated with disease severity in COVID-19 patients*
**作者**：Chen, Z. et al.
**摘要**：通过流式细胞术结合抗CD127抗体，发现COVID-19重症患者外周血中CD127阳性单核细胞比例升高，提示其作为炎症进展的潜在生物标志物。
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如需具体文献，建议通过PubMed或Google Scholar搜索关键词“CD127 antibody”、“IL7RA monoclonal antibody”获取最新研究。部分研究可能涉及抗体在癌症、免疫缺陷或流式检测中的应用。
CD127. also known as the interleukin-7 receptor alpha chain (IL-7Rα), is a key component of the heterodimeric receptor for IL-7. a cytokine critical for lymphocyte development, survival, and homeostasis. Paired with the common gamma chain (γc), CD127 mediates IL-7 signaling, which is essential for T-cell maturation in the thymus, peripheral T-cell maintenance, and memory T-cell generation. Dysregulation of CD127 expression or function has been linked to immune disorders, including severe combined immunodeficiency (SCID), autoimmune diseases, and lymphoproliferative conditions.
CD127 antibodies are vital tools for studying immune cell subsets. For example, CD127 is downregulated in regulatory T cells (Tregs) but highly expressed in effector T cells, enabling their distinction in flow cytometry. In research, these antibodies help elucidate IL-7/STAT5 signaling pathways and their roles in immune reconstitution, such as in HIV or post-hematopoietic stem cell transplantation. Therapeutically, CD127-targeting strategies are explored to modulate immune responses in autoimmunity or cancer by blocking IL-7-driven T-cell proliferation.
Variability in antibody clones (e.g., recognizing different epitopes) requires careful validation to ensure specificity. Additionally, soluble CD127 levels are studied as biomarkers in chronic inflammation and immune aging. Recent studies also highlight CD127’s role in lymphoid malignancies, where aberrant signaling may promote tumor survival. Overall, CD127 antibodies remain indispensable for dissecting immune biology and developing targeted therapies.
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