Rabbit Monoclonal BAT3 Antibody

BAT3 (HLA-B-associated transcript 3), also known as Bag6 or Scythe, is a multifunctional protein involved in critical cellular processes such as protein quality control, apoptosis, DNA repair, and immune regulation. It acts as a chaperone in the endoplasmic reticulum-associated degradation (ERAD) pathway, facilitating the ubiquitination and degradation of misfolded proteins. Structurally, BAT3 contains a ubiquitin-like (UBL) domain and a proline-rich region, enabling interactions with components of the ubiquitin-proteasome system and stress-responsive signaling molecules. In apoptosis, BAT3 modulates the activity of apoptotic regulators like ARC and p53. Additionally, it plays a role in MHC class I antigen presentation by assisting in peptide loading onto HLA-B molecules. BAT3 antibodies are essential tools in research, used to detect and study its expression, localization, and interactions in contexts like cancer (where it may influence tumor suppression or chemoresistance), neurodegenerative diseases, and immune disorders. Dysregulation of BAT3 has been linked to pathological conditions, making its study crucial for understanding cellular stress responses and therapeutic targeting. These antibodies are widely applied in techniques such as Western blotting, immunoprecipitation, and immunofluorescence.