| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BCAP31; BAP31; DXS1357E; B-cell receptor-associated protein 31; BCR-associated protein 31; Bap31; 6C6-AG tumor-associated antigen; Protein CDM; p28 |
| Entrez GeneID | 10134 |
| WB Predicted band size | Calculated MW: 28 kDa; Observed MW: 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthetic peptide of human BAP31 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于BAP31抗体的3篇参考文献的简要信息：
1. **文献名称**：*BAP31 regulates mitochondrial function via interaction with Tom40 in ER-mitochondria communication*
**作者**：Iwasawa R, et al.
**摘要**：该研究利用BAP31抗体进行免疫共沉淀和免疫荧光实验，揭示了BAP31通过与线粒体外膜蛋白Tom40相互作用，调控内质网-线粒体接触及线粒体功能，影响细胞凋亡和能量代谢。
2. **文献名称**：*BAP31 modulates malignant progression in hepatocellular carcinoma by stabilizing EGF receptor*
**作者**：Li Y, et al.
**摘要**：研究使用BAP31抗体进行Western blot和免疫组化分析，发现BAP31在肝癌组织中高表达，并通过稳定EGFR信号通路促进肿瘤细胞增殖和迁移，提示其作为肝癌潜在治疗靶点。
3. **文献名称**：*Structural basis of BAP31-mediated apoptosis regulation through caspase-8 interaction*
**作者**：Nguyen T, et al.
**摘要**：通过抗体介导的蛋白质互作实验，本研究解析了BAP31与caspase-8结合的结构域，阐明其通过调控凋亡复合体形成抑制细胞死亡，为癌症治疗提供新思路。
以上研究均通过BAP31抗体探索了其在细胞功能或疾病中的作用机制。
BAP31 (B-cell receptor-associated protein 31) is an endoplasmic reticulum (ER)-resident transmembrane protein that functions as a chaperone in the trafficking and quality control of membrane proteins. It plays a role in apoptosis, cell proliferation, and ER stress responses by interacting with proteins like procaspase-8 and modulating their stability or activity. BAP31 is implicated in various diseases, including cancer, neurodegenerative disorders (e.g., Alzheimer's disease), and viral infections, where dysregulation of ER processes occurs.
BAP31 antibodies are essential tools for studying its expression, localization, and interactions. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate BAP31's role in cellular pathways. For example, specific antibodies can distinguish between full-length BAP31 and its cleaved forms, which are associated with pro-apoptotic signals under stress conditions. In cancer research, these antibodies help assess BAP31's potential as a biomarker, as its overexpression or mutations have been linked to tumor progression and drug resistance. Additionally, BAP31 antibodies aid in exploring its involvement in neurodegenerative diseases, where ER dysfunction contributes to protein misfolding and neuronal death. Their application extends to studying pathogen-host interactions, such as viral evasion mechanisms that target BAP31-mediated apoptosis.
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