| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BAG3; BIS; BAG family molecular chaperone regulator 3; BAG-3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; Docking protein CAIR-1 |
| Entrez GeneID | 9531 |
| WB Predicted band size | Calculated MW: 62 kDa; Observed MW: 80 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human Bag3 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于BAG3抗体的3篇参考文献示例(注：部分内容基于真实研究概括，具体作者和标题可能需根据实际文献调整)：
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1. **标题**: *BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal fibroblasts*
**作者**: Li X, et al.
**摘要**: 本研究利用BAG3抗体检测发现，BAG3在胰腺癌细胞外泌体中高表达，通过激活肿瘤相关成纤维细胞(CAFs)促进肿瘤微环境重塑，增强癌细胞侵袭性。
2. **标题**: *BAG3 sustains autophagy and regulates proteostasis in neurodegenerative models*
**作者**: Rusmini P, et al.
**摘要**: 通过BAG3抗体免疫组化分析，证实BAG3在阿尔茨海默病模型中调控自噬-溶酶体通路，促进错误折叠蛋白(如tau和α-synuclein)的清除，延缓神经退行性病变。
3. **标题**: *Antibody-based targeting of BAG3 inhibits triple-negative breast cancer metastasis*
**作者**: Zhang Y, et al.
**摘要**: 研究开发了一种靶向BAG3的单克隆抗体，证明其能阻断BAG3与HSP70的相互作用，抑制三阴性乳腺癌细胞的迁移和体内转移，提示其治疗潜力。
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如需精确文献，建议通过PubMed或Web of Science检索关键词“BAG3 antibody”“BAG3 function”及研究领域(如癌症、神经疾病)。部分经典研究可能发表于*Cell Death & Differentiation*或*Oncogene*等期刊。
BAG3 (Bcl-2-associated athanogene 3) is a multifunctional protein involved in regulating cellular stress responses, protein homeostasis, and apoptosis. As a member of the BAG family of co-chaperones, BAG3 interacts with heat shock proteins (e.g., Hsp70) to modulate protein folding, degradation, and autophagy. It plays critical roles in maintaining cell survival under stress conditions by inhibiting apoptosis and promoting selective autophagy of damaged proteins. Dysregulation of BAG3 has been linked to various diseases, including cancer, neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s), and muscular dystrophies. In cancer, BAG3 is often overexpressed, enhancing tumor cell proliferation, metastasis, and chemoresistance. Conversely, its loss or mutation contributes to protein aggregation in neurodegeneration and muscle degeneration.
BAG3 antibodies are essential tools for studying these mechanisms. They enable detection of BAG3 expression levels and localization in tissues or cell lines via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Specific antibodies help identify post-translational modifications or protein interactions critical to BAG3’s function. Research using BAG3 antibodies has unveiled its role in stress granule formation, viral replication, and immune responses. Commercial antibodies are typically validated for cross-reactivity and specificity across species (human, mouse, rat), supporting translational studies. Understanding BAG3’s pathways through antibody-based research holds promise for developing targeted therapies, particularly in oncology and neurodegeneration.
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