| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BAG1; HAP; BAG family molecular chaperone regulator 1; BAG-1; Bcl-2-associated athanogene 1 |
| Entrez GeneID | 573 |
| WB Predicted band size | Calculated MW: 39 kDa; Observed MW: 52,46,33 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human Bag1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于BAG1抗体的3篇参考文献示例，包含文献名称、作者和摘要内容概括：
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1. **文献名称**: *BAG-1: A multifunctional regulator of cell growth and survival*
**作者**: Takayama S, Reed JC
**摘要**: 该研究探讨了BAG1蛋白作为Hsp70分子伴侣共调控因子的功能，揭示了其通过抑制凋亡信号通路(如与BCL-2协同作用)促进细胞存活的机制，并验证了抗体在检测BAG1亚细胞定位中的应用。
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2. **文献名称**: *BAG1 expression correlates with prognosis in colorectal cancer through immune modulation*
**作者**: Cutress RI, et al.
**摘要**: 文章利用BAG1抗体进行免疫组化分析，发现BAG1在结直肠癌组织中的高表达与患者生存率改善相关，提示其可能通过调控肿瘤微环境中的免疫应答影响预后。
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3. **文献名称**: *BAG1 as a biomarker in neurodegenerative diseases: Insights from Alzheimer's models*
**作者**: Kögel D, et al.
**摘要**: 研究通过Western blot和免疫荧光技术，发现BAG1在阿尔茨海默病模型中与tau蛋白异常磷酸化相关，表明其可能通过调节蛋白质稳态参与神经退行性病变。
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4. **文献名称**: *Targeting BAG1 in cancer therapy: Mechanisms and antibody-based approaches*
**作者**: Dai C, Sampson SB
**摘要**: 综述总结了BAG1在肿瘤中的促存活作用，并讨论了利用特异性抗体靶向BAG1以增强化疗敏感性的潜在策略，强调其在乳腺癌和肺癌中的治疗价值。
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这些文献涵盖了BAG1在癌症、神经疾病中的功能研究及抗体应用场景。如需具体文章链接或补充信息，可进一步提供方向。
**Background of BAG1 Antibody**
BAG1 (Bcl-2 associated athanogene 1) is a multifunctional protein belonging to the BAG family, which acts as a co-chaperone regulator of heat shock proteins (HSPs), particularly Hsp70/Hsc70. It modulates protein folding, degradation, and stress response by binding to the ATPase domain of Hsp70 via its conserved BAG domain. BAG1 exists in multiple isoforms (e.g., p50. p46. p33) generated by alternative splicing, differing in subcellular localization (nuclear or cytoplasmic) and functional roles.
BAG1 is implicated in critical cellular processes, including apoptosis, proliferation, and differentiation. It enhances cell survival by interacting with anti-apoptotic proteins like Bcl-2 and regulating signaling pathways such as MAPK/ERK. Dysregulation of BAG1 is linked to cancer, neurodegenerative diseases, and stress-related disorders. In cancer, BAG1 overexpression is observed in breast, colorectal, and prostate tumors, where it may serve as a prognostic marker or therapeutic target.
BAG1 antibodies are essential tools for detecting BAG1 expression and studying its role in disease mechanisms. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore BAG1’s interaction networks, localization, and expression patterns in pathological conditions. Research using BAG1 antibodies also aims to dissect its dual roles in promoting cell survival (in cancer) or contributing to protein aggregation (in neurodegeneration), highlighting its therapeutic potential.
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