Rabbit Monoclonal ATG4C Antibody

ATG4C antibody is a research tool targeting the autophagy-related protein ATG4C, a member of the ATG4 cysteine protease family critical for autophagosome formation. Autophagy, a cellular degradation pathway, relies on ATG4 proteases to process LC3 (microtubule-associated protein 1A/1B-light chain 3) proteins by cleaving their C-terminal residues, enabling LC3 conjugation to phagophore membranes—a key step in autophagosome maturation. ATG4C, encoded by the ATG4C gene, also facilitates LC3 delipidation during autophagosome-lysosome fusion, recycling LC3 for subsequent autophagy cycles. While ATG4A and ATG4B are more extensively studied, ATG4C’s role appears context-dependent, with studies linking it to selective autophagy processes and stress responses. Dysregulation of ATG4C has been implicated in cancer, neurodegenerative diseases, and metabolic disorders, making it a potential therapeutic target. The ATG4C antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect protein expression, localization, and interactions. Its specificity is validated using knockout controls or siRNA-mediated knockdown. Commercial ATG4C antibodies are often raised against recombinant protein fragments or synthetic peptides, with applications spanning basic autophagy research and disease mechanism studies. Ongoing research aims to clarify its distinct functions and regulatory mechanisms, including post-translational modifications that modulate its protease activity.