| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; CD11b; Leukocyte adhesion receptor MO1 |
| Entrez GeneID | 16409 |
| WB Predicted band size | Calculated MW: 127 kDa; Observed MW: 170 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | A synthetic peptide of mouse CD11b |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于CD11b抗体的参考文献及其摘要概述：
1. **"CD11b regulates murine neutrophil recruitment in response to endotoxin"**
*作者：D. L. Williams et al.*
摘要：研究通过CD11b抗体阻断实验，揭示了CD11b在中性粒细胞向炎症部位迁移中的关键作用，并证明其通过调控细胞黏附和趋化因子信号通路影响脓毒症模型中的免疫反应。
2. **"Targeting CD11b for imaging of acute cerebral ischemia using antibody-conjugated nanoparticles"**
*作者：K. Y. Lee et al.*
摘要：开发了一种CD11b抗体偶联的纳米探针，用于特异性标记活化的单核/巨噬细胞，证明其在缺血性中风模型中通过MRI检测早期脑损伤的潜力。
3. **"CD11b+ myeloid cells mediate phenotypic switching of adipose tissue macrophages in obesity"**
*作者：A. M. Jaiswal et al.*
摘要：利用CD11b抗体分选技术，阐明了肥胖条件下CD11b+髓系细胞通过分泌炎性因子促进脂肪组织巨噬细胞表型极化，进而驱动代谢性炎症的机制。
(注：以上文献信息为示例性内容，实际文献需通过PubMed等数据库检索获取。)
CD11b, a subunit of the integrin family (paired with CD18 to form Mac-1/αMβ2), is a cell surface receptor predominantly expressed on myeloid cells, including monocytes, macrophages, neutrophils, and dendritic cells. It plays critical roles in immune responses, mediating cell adhesion, migration, and pathogen recognition by binding ligands such as complement component iC3b, fibrinogen, and intercellular adhesion molecules (e.g., ICAM-1). CD11b antibodies are widely used as research tools to identify and isolate myeloid cell populations via flow cytometry, immunohistochemistry, or functional studies.
These antibodies target the CD11b protein's extracellular domain, often recognizing epitopes involved in ligand binding or conformational activation. In research, CD11b antibodies help elucidate mechanisms in inflammation, autoimmune diseases, and cancer, where myeloid cell infiltration and activity are key. Clinically, they have potential in diagnostics (e.g., monitoring leukocyte activation) and therapeutic development, as CD11b modulation may influence immune cell trafficking or effector functions.
Recent studies also explore CD11b's role in immunometabolism and crosstalk with signaling pathways like TLRs. However, functional heterogeneity across antibody clones (e.g., blocking vs. activating effects) requires careful selection for specific applications. Overall, CD11b antibodies remain indispensable for dissecting myeloid cell biology and advancing immune-targeted therapies.
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