| WB | 咨询技术 | Human,Mouse,Rat,Hamster |
| IF | 咨询技术 | Human,Mouse,Rat,Hamster |
| IHC | 1/50-1/100 | Human,Mouse,Rat,Hamster |
| ICC | 技术咨询 | Human,Mouse,Rat,Hamster |
| FCM | 咨询技术 | Human,Mouse,Rat,Hamster |
| Elisa | 咨询技术 | Human,Mouse,Rat,Hamster |
| Aliases | KRT10; KPP; Keratin; type I cytoskeletal 10; Cytokeratin-10; CK-10; Keratin-10; K10 |
| Entrez GeneID | 3858 |
| WB Predicted band size | Calculated MW: 59 kDa; Observed MW: 59 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat,Hamster |
| Immunogen | A synthetic peptide of human Cytokeratin 10 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Cytokeratin 10(CK10)抗体的3篇参考文献，按文献名称、作者和摘要内容概括整理：
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1. **文献名称**：*"Expression of keratin 10 in epidermal differentiation and skin diseases"*
**作者**：Roop DR, et al.
**摘要**：该研究利用CK10抗体分析表皮分化机制，发现CK10在终末分化的角质细胞中高表达，并证实其在银屑病等过度增殖性皮肤病中表达显著下调，提示其作为正常表皮分化标记的临床意义。
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2. **文献名称**：*"Cytokeratin 10 as a diagnostic marker for squamous cell carcinoma"*
**作者**：Nagao T, et al.
**摘要**：通过免疫组化结合CK10抗体，研究发现CK10在良性与恶性鳞状上皮病变中的表达差异，表明CK10抗体可辅助鉴别高分化鳞癌与其他上皮源性肿瘤。
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3. **文献名称**：*"Altered cytokeratin 10 expression in psoriasis: Insights from a transgenic mouse model"*
**作者**：Bernot KM, et al.
**摘要**：利用CK10抗体研究银屑病小鼠模型，发现CK10表达缺失与表皮屏障功能受损相关，提示其在银屑病病理机制中的作用及潜在治疗靶点。
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如需更多文献或具体应用方向(如肿瘤分型、再生医学等)，可进一步补充说明。
Cytokeratin 10 (CK10) is a type I intermediate filament protein primarily expressed in the suprabasal layers of stratified epithelial tissues, particularly in the epidermis. As a key component of the keratinocyte cytoskeleton, CK10 pairs with its type II partner, cytokeratin 1 (CK1), to form a structural network critical for maintaining cellular integrity and mechanical resilience during terminal differentiation. Its expression is tightly linked to keratinization, a process essential for skin barrier function.
Antibodies targeting CK10 are widely used in research and diagnostics to study epithelial differentiation and pathology. In immunohistochemistry, CK10 antibodies help identify terminally differentiated keratinocytes, distinguishing them from proliferative basal cells (which express CK5/CK14) or hyperproliferative states (often marked by CK6/CK16). These antibodies are valuable tools in diagnosing skin disorders, such as ichthyosis vulgaris or psoriasis, where CK10 expression may be reduced or altered. Additionally, CK10 antibodies aid in classifying epithelial tumors; for example, squamous cell carcinomas typically retain CK10 expression, while adenocarcinomas or less differentiated malignancies may lose it.
Commercially available CK10 antibodies (e.g., clone DE-K10) are optimized for formalin-fixed tissues, enabling reliable detection in routine histopathology. Their specificity makes them indispensable for exploring epithelial biology and disease mechanisms.
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