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Rabbit Monoclonal USP11 Antibody

  • 中文名: USP11抗体
  • 别    名: UHX1; USP11
货号: IPDX20951
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesUHX1; USP11
Entrez GeneID8237
WB Predicted band sizeCalculated MW: 110 kDa; Observed MW: 110 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenA synthetic peptide of human USP11
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于USP11抗体的3篇代表性文献的简要总结:

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1. **文献名称**:*USP11 regulates PML stability to control Notch-induced malignancy in brain tumours*

**作者**:Zhu et al.

**摘要**:该研究揭示了USP11通过去泛素化稳定PML蛋白,调控Notch信号通路,从而影响胶质母细胞瘤的进展。研究中利用USP11抗体进行免疫共沉淀(Co-IP)和Western blot验证其与PML的相互作用。

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2. **文献名称**:*USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation and tumor progression*

**作者**:Luo et al.

**摘要**:本文发现USP11通过去泛素化RAE1调控纺锤体形成,影响染色体稳定性。研究使用USP11抗体进行免疫荧光染色,证实其在有丝分裂中的亚细胞定位,并证明USP11高表达与乳腺癌患者预后不良相关。

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3. **文献名称**:*USP11 modulates autophagy and antiviral immune responses by deubiquitinating Beclin-1*

**作者**:Xia et al.

**摘要**:该研究阐明USP11通过去泛素化Beclin-1调控自噬和抗病毒免疫反应。作者通过USP11抗体敲低实验和ChIP-seq分析,揭示了其在抗病毒信号中的新功能。

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这些文献均涉及USP11抗体的实验应用(如Western blot、Co-IP、免疫荧光),并探讨了USP11在癌症、细胞周期和免疫调控中的分子机制。如需具体文献来源,可进一步检索PubMed或SciHub获取全文。

背景信息

The USP11 antibody targets ubiquitin-specific protease 11 (USP11), a deubiquitinating enzyme (DUB) belonging to the USP family. USP11 regulates critical cellular processes by removing ubiquitin chains from substrate proteins, thereby modulating their stability, localization, or activity. It plays roles in DNA repair, cell cycle control, immune response, and apoptosis, interacting with key substrates such as BRCA2. IκBα, and p53. Dysregulation of USP11 is linked to cancer, neurodegenerative disorders, and viral infections. For example, it may act as an oncogene by stabilizing prometastatic proteins or as a tumor suppressor by enhancing DNA repair. USP11 antibodies are essential tools for studying its expression, post-translational modifications, and mechanistic roles in disease. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence. Researchers also employ these antibodies to explore USP11's therapeutic potential, as inhibitors are being investigated for cancer treatment. Available as monoclonal or polyclonal forms, USP11 antibodies vary in specificity and applications, requiring validation for experimental contexts. Understanding USP11's dual roles continues to drive interest in developing targeted therapies and biomarkers.

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