| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | cadherin 4; type 1; R-cadherin (retinal); CAD4; RCAD; R-CAD |
| Entrez GeneID | 1002 |
| WB Predicted band size | Calculated MW: 100 kDa; Observed MW: 130 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human R Cadherin |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于R-cadherin抗体的参考文献(虚构示例，仅供参考)：
1. **《R-cadherin regulates neural crest cell migration during embryonic development》**
- 作者：Smith A, et al.
- 摘要：研究通过特异性R-cadherin抗体发现其在神经嵴细胞迁移中的作用，揭示R-cadherin通过介导细胞间黏附影响胚胎发育中的组织模式形成。
2. **《A monoclonal antibody against R-cadherin inhibits tumor metastasis in vivo》**
- 作者：Yamamoto T, et al.
- 摘要：开发了一种靶向R-cadherin的单克隆抗体，体外实验显示其可阻断癌细胞侵袭，体内实验证实抑制肿瘤转移，提示其作为癌症治疗工具的潜力。
3. **《R-cadherin expression dynamics in retinal synaptic circuit formation》**
- 作者：Lee C, et al.
- 摘要：利用R-cadherin抗体进行免疫组化分析，发现其在视网膜神经元突触连接中的时空表达模式，表明其对视觉系统神经回路建立的调控作用。
注：以上文献为模拟示例，实际研究需通过PubMed或Google Scholar检索关键词(如“R-cadherin antibody”“CDH4”)获取真实文献。
R Cadherin (Retinal Cadherin), also known as Cadherin-4 (CDH4), is a calcium-dependent cell adhesion molecule belonging to the type II classical cadherin subfamily. It plays critical roles in tissue morphogenesis, neural circuit formation, and cell-cell recognition by mediating homophilic interactions between adjacent cells. Structurally, it features extracellular cadherin repeats for calcium-binding and adhesion, a transmembrane domain, and a cytoplasmic tail that interacts with catenins to link the actin cytoskeleton.
R Cadherin is prominently expressed in the nervous system, particularly during retinal development, where it guides axon targeting and synaptic specificity. It also contributes to organogenesis in tissues like the kidney and lung. Dysregulation of R Cadherin has been implicated in neurological disorders and cancers, including gliomas and colorectal cancer, where altered expression may influence tumor invasiveness or metastasis.
Antibodies targeting R Cadherin are essential tools for studying its spatial-temporal expression, localization, and function. They are widely used in techniques such as immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting. Validated antibodies help elucidate R Cadherin’s role in developmental biology, disease mechanisms, and potential therapeutic targeting. Specificity is ensured through knockout controls or peptide-blocking assays, making them indispensable for both basic and translational research.
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