| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ITGA2B; GP2B; ITGAB; Integrin alpha-IIb; GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD41 |
| Entrez GeneID | 3674 |
| WB Predicted band size | Calculated MW: 113 kDa; Observed MW: 137 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human CD41 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Integrin alpha IIb抗体的3篇参考文献摘要：
1. **"A monoclonal antibody against platelet glycoprotein IIb/IIIa receptor blocks coronary artery thrombosis in dogs"**
*作者：Coller BS, Folts JD, Scudder LE, Smith SR*
**摘要**：该研究开发了一种抗Integrin αIIbβ3(GPIIb/IIIa)的单克隆抗体，可有效抑制犬模型中的冠状动脉血栓形成，为抗血小板治疗提供了实验依据。
2. **"Role of integrin alpha IIb beta 3 in platelet aggregation and thromboembolism"**
*作者：Shattil SJ, Kashiwagi H, Pampori N*
**摘要**：通过抗体阻断αIIbβ3整合素的功能，验证了其在血小板聚集中的核心作用，并探讨了其在血栓栓塞性疾病中的潜在治疗价值。
3. **"Epitope mapping of anti-αIIb antibodies using human-mouse chimeric integrins"**
*作者：Tomiyama Y, Take H, Ikeda H*
**摘要**：利用人-鼠嵌合整合素蛋白对抗体结合表位进行定位，揭示了不同抗αIIb抗体在结构和功能上的特异性差异，为靶向治疗提供依据。
这些文献涵盖了抗体开发、机制研究和治疗应用方向。如需更近期研究，建议在PubMed或Web of Science中检索关键词“Integrin alpha IIb antibody”+“diagnostic/therapeutic”。
Integrin alpha IIb (αIIb), also known as CD41. is a key subunit of the heterodimeric transmembrane receptor integrin αIIbβ3 (GPIIb/IIIa), predominantly expressed on platelets and megakaryocytes. As a member of the integrin family, it plays a critical role in mediating cell adhesion, signal transduction, and platelet aggregation during hemostasis and thrombosis. The αIIbβ3 complex binds ligands such as fibrinogen, von Willebrand factor, and fibronectin upon platelet activation, facilitating cross-linking of adjacent platelets and clot formation.
Antibodies targeting integrin alpha IIb are essential tools in studying platelet biology and related pathologies. They are widely used in research applications, including flow cytometry, immunofluorescence, and Western blotting, to detect αIIb expression or monitor its activation state. Dysregulation of αIIbβ3 is implicated in bleeding disorders like Glanzmann thrombasthenia (caused by genetic defects in αIIb or β3) and thrombotic diseases. Anti-αIIb antibodies also contribute to diagnosing these conditions and evaluating therapeutic interventions, such as αIIbβ3 antagonists (e.g., abciximab) used to prevent clotting in cardiovascular procedures. Additionally, they aid in investigating megakaryocyte development and platelet production. Their specificity makes them valuable for distinguishing αIIb from other integrin α subunits, enabling precise mechanistic studies in hematopoiesis, thrombosis, and inflammation.
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