| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CD146; MUC18 |
| Entrez GeneID | 4162 |
| WB Predicted band size | Calculated MW: 72 kDa; Observed MW: 120 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human CD146 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
+ +
以下是3篇关于CD146抗体的参考文献(注：以下内容为模拟示例，实际文献需通过学术数据库查询)：
1. **文献名称**：CD146 as a biomarker for tumor angiogenesis and a potential therapeutic target
**作者**：Zheng, C., et al.
**摘要**：该研究探讨了CD146在肿瘤血管生成中的关键作用，证明其抗体可通过阻断血管内皮细胞中的CD146信号通路抑制肿瘤生长，提示其作为抗血管生成治疗的潜在靶点。
2. **文献名称**：Structural basis of CD146 recognition by a humanized antibody for cancer therapy
**作者**：Li, Y., et al.
**摘要**：通过解析CD146与人类源化抗体的复合物晶体结构，揭示了抗体结合CD146表位的分子机制，为优化靶向CD146的癌症免疫疗法提供结构基础。
3. **文献名称**：CD146 antibody-linked immunosensor for early detection of metastatic melanoma
**作者**：Wang, X., et al.
**摘要**：开发了一种基于CD146抗体的电化学免疫传感器，能够高灵敏度检测黑色素瘤患者血液中的CD146水平，助力转移性肿瘤的早期诊断。
如需具体文献，建议通过PubMed或Web of Science检索关键词“CD146 antibody”或“MCAM antibody”获取最新研究。
CD146. also known as Melanoma Cell Adhesion Molecule (MCAM) or MUC18. is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Initially identified as a marker for melanoma progression, it is expressed in various cell types, including endothelial cells, smooth muscle cells, and immune cells. CD146 plays critical roles in cell adhesion, migration, angiogenesis, and signal transduction, participating in processes like vascular development, immune response, and tumor metastasis.
CD146 antibodies are tools developed to target specific epitopes of this protein for research, diagnostic, or therapeutic purposes. In research, these antibodies help elucidate CD146's biological functions, such as its involvement in endothelial barrier regulation or cancer cell dissemination. Clinically, CD146 is implicated in pathologies like cancer, inflammatory diseases, and vascular disorders. Overexpression of CD146 in tumors (e.g., melanoma, prostate, and ovarian cancers) correlates with aggressive phenotypes and poor prognosis, making it a potential therapeutic target.
Therapeutic CD146 antibodies are being explored to block pro-metastatic signaling or inhibit angiogenesis in cancers. Diagnostic applications leverage its expression patterns as biomarkers for disease monitoring. Additionally, CD146 antibodies are used in techniques like flow cytometry, immunohistochemistry, and Western blotting to study protein localization and expression levels. Challenges remain in optimizing specificity and minimizing off-target effects, but ongoing studies continue to expand their utility in both basic science and clinical contexts.
×
