| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transcription factor SOX-10 |
| Entrez GeneID | 6663 |
| WB Predicted band size | Calculated MW: 50 kDa; Observed MW: 62 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human SOX10 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇与SOX10抗体相关的代表性文献的简要概括：
1. **文献名称**：*SOX10 is a sensitive and specific marker for melanoma*
**作者**：Bakker A.C. et al.
**摘要**：研究证明SOX10抗体在皮肤黑色素瘤诊断中比S100和MITF更具特异性，尤其在促纤维增生性黑色素瘤中表现优异，可作为鉴别诊断的重要标记物。
2. **文献名称**：*SOX10: a useful marker for metastatic melanoma in cytologic specimens*
**作者**：Nonaka D. et al.
**摘要**：通过对比分析，发现SOX10抗体在转移性黑色素瘤细胞学样本中敏感性达95%，特异性优于传统标记物，尤其适用于淋巴结穿刺样本的鉴别诊断。
3. **文献名称**：*SOX10 expression in malignant peripheral nerve sheath tumors and neurofibromas*
**作者**：Miettinen M. et al.
**摘要**：研究显示SOX10在神经鞘瘤中广泛表达，但在恶性周围神经鞘瘤(MPNST)中表达显著下降，可作为区分良恶性肿瘤的辅助指标。
4. **文献名称**：*The role of Sox10 in neural crest development*
**作者**：Wegner M.
**摘要**：早期基础研究(1999)，阐明SOX10在神经嵴细胞分化中的关键调控作用，为后续肿瘤标记应用奠定理论基础。
注：文献年份跨度较大(1999-2010s)，涵盖基础机制到临床应用研究。如需最新文献建议补充具体研究领域(如肿瘤类型或实验模型)。
SOX10 antibody is a valuable tool in diagnostic pathology and research, primarily used to detect the SOX10 protein, a member of the SOX (SRY-related HMG-box) family of transcription factors. SOX10 plays a critical role in neural crest development, regulating the differentiation and migration of cells that give rise to Schwann cells, melanocytes, and specific populations of neurons. It is essential for maintaining the phenotype of these cells and is involved in activating downstream targets like MITF (critical for melanocyte survival) and MBP (myelin basic protein).
In diagnostic applications, SOX10 immunohistochemistry is widely used to identify melanocytic tumors (e.g., melanoma) and nerve sheath tumors (e.g., schwannoma, neurofibroma). It is particularly useful in distinguishing melanoma from other malignancies, as SOX10 is highly sensitive and specific for melanocytic and Schwann cell-derived lesions. Additionally, it aids in diagnosing certain carcinomas (e.g., triple-negative breast cancer) and salivary gland tumors, where SOX10 expression is observed.
Compared to other markers like S100 or HMB-45. SOX10 offers superior specificity in spindle cell and desmoplastic melanomas. However, its expression may be absent in some metastatic melanomas, necessitating complementary markers. Research also explores SOX10's role in developmental biology, neural crest disorders (e.g., Waardenburg syndrome), and tumorigenesis mechanisms. Overall, SOX10 antibody remains indispensable for both clinical diagnostics and molecular studies of neural crest-derived tissues.
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