Rabbit Monoclonal GAD67 Antibody

GAD67 antibody is an autoantibody targeting glutamate decarboxylase 67 (GAD67), an enzyme encoded by the GAD1 gene. GAD67 catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. Alongside its isoform GAD65 (encoded by GAD2), GAD67 plays a critical role in maintaining GABAergic signaling, which regulates neuronal excitability. While GAD65 antibodies are more commonly associated with autoimmune neurological disorders (e.g., stiff-person syndrome, cerebellar ataxia), GAD67 antibodies are less frequently detected but have been implicated in certain autoimmune conditions, including type 1 diabetes and rare neurological syndromes. In research, GAD67 antibodies are widely used as immunohistochemical markers to identify GABA-producing neurons in brain studies. Elevated GAD67 autoantibodies may indicate autoimmune dysfunction, though their clinical significance remains less defined compared to GAD65. Detection methods like ELISA or immunohistochemistry help diagnose autoimmune disorders or map inhibitory neurons in neuroanatomical research. The presence of GAD67 antibodies in diseases underscores the interplay between GABA metabolism and autoimmunity, though further studies are needed to clarify their pathogenic mechanisms.