| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA'; PECA1; CD antigen CD31 |
| Entrez GeneID | 5175 |
| clone | 5C12 |
| WB Predicted band size | Calculated MW: 83 kDa; Observed MW: 130 kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant human CD31 protein fragments expressed in E.coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于CD31抗体的3-4条参考文献的简要整理：
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1. **文献名称**：*PECAM-1: Structure, Function, and Role in Vascular Biology*
**作者**：Newman, P.J.
**摘要**：该综述系统总结了CD31(PECAM-1)的分子结构、生物学功能及其在内皮细胞黏附、炎症反应和血管生成中的作用，强调其在血管生物学研究中的关键地位。
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2. **文献名称**：*Involvement of PECAM-1 in Angiogenesis and Vascular Development*
**作者**：DeLisser, H.M. et al.
**摘要**：通过基因敲除和抗体阻断实验，研究证实CD31在血管形成和胚胎发育中不可或缺，其介导的细胞间相互作用对血管网络的形成和稳定至关重要。
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3. **文献名称**：*CD31 as a Marker for Tumor Vasculature: Applications in Immunohistochemistry*
**作者**：Albelda, S.M. et al.
**摘要**：探讨CD31抗体在肿瘤微环境研究中的应用，验证其作为内皮细胞特异性标记在评估肿瘤血管密度和抗血管治疗中的诊断价值。
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4. **文献名称**：*Role of PECAM-1 in Leukocyte Transmigration*
**作者**：Muller, W.A.
**摘要**：研究揭示CD31通过介导白细胞与内皮细胞的相互作用，促进炎症部位的白细胞跨内皮迁移，为免疫调控和炎症疾病机制提供新见解。
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这些文献覆盖了CD31的基础生物学功能、血管生成、肿瘤研究及免疫学应用等方向。
CD31 antibody targets the CD31 protein, also known as Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1), a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Expressed predominantly on vascular endothelial cells, platelets, and certain immune cells, CD31 plays critical roles in cell adhesion, angiogenesis, and inflammatory responses. Its structure includes six extracellular immunoglobulin-like domains, a transmembrane region, and a cytoplasmic tail involved in intracellular signaling. CD31 mediates homophilic interactions between adjacent endothelial cells to maintain vascular integrity and facilitates leukocyte transendothelial migration during inflammation.
In research and diagnostics, CD31 antibodies are widely used as endothelial markers to identify blood vessels in tissues, aiding in the study of vascularization in tumors, wound healing, and cardiovascular diseases. They are essential tools in immunohistochemistry and flow cytometry to assess endothelial cell presence, distribution, and pathological alterations. Additionally, CD31’s involvement in angiogenesis has made its antibody valuable in cancer research, particularly in evaluating tumor microenvironments and anti-angiogenic therapies. Dysregulation of CD31 is also linked to autoimmune disorders and atherosclerosis, highlighting its relevance in immunology and vascular biology.
Overall, CD31 antibodies serve as pivotal reagents for investigating vascular biology, inflammatory mechanisms, and disease progression, bridging basic research with clinical applications.
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