| WB | 咨询技术 | Human,Monkey |
| IF | 1/20 | Human,Monkey |
| IHC | 咨询技术 | Human,Monkey |
| ICC | 1/50-1/200 | Human,Monkey |
| FCM | 咨询技术 | Human,Monkey |
| Elisa | 咨询技术 | Human,Monkey |
| Aliases | CDX2; CDX3; Homeobox protein CDX-2; CDX-3; Caudal-type homeobox protein 2 |
| Entrez GeneID | 1045 |
| clone | 7H3 |
| WB Predicted band size | Calculated MW: 34 kDa; Observed MW: 34 kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Monkey |
| Immunogen | Purified recombinant human CDX2 protein fragments expressed in E.coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于CDX2抗体的3篇代表性文献的简要信息整理：
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1. **文献名称**: *CDX2 as a Marker for Intestinal Differentiation: Its Utility in Diagnosing Metastatic Carcinomas of Unknown Origin*
**作者**: Werling RW, et al.
**摘要**: 该研究验证了CDX2抗体在鉴别转移性腺癌组织起源中的应用，发现CDX2在结直肠癌中高特异性表达(约95%)，而在肺、乳腺等其他癌症中极少表达，支持其作为肠道分化的可靠标记物。
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2. **文献名称**: *CDX2 Immunostaining in the Classification of Gastroenteropancreatic Neuroendocrine Neoplasms*
**作者**: Barbareschi M, et al.
**摘要**: 研究探讨CDX2抗体在胃肠胰神经内分泌肿瘤(GEP-NENs)中的表达模式，发现CDX2在回肠和结肠神经内分泌瘤中高表达，而在胰腺NENs中缺失，提示其可用于肿瘤起源定位及亚型分类。
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3. **文献名称**: *Loss of CDX2 Expression is Associated with Poor Prognosis in Colorectal Cancer*
**作者**: Dalerba P, et al.
**摘要**: 通过免疫组化分析发现，CDX2表达缺失与结直肠癌患者生存率下降显著相关，表明CDX2不仅是分化标记物，还可能作为预后评估的生物标志物，为临床治疗决策提供参考。
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如需获取具体文献全文或补充信息，建议通过PubMed或期刊官网检索标题及作者。
The CDX2 antibody is a valuable tool in diagnostic pathology and research, primarily used to detect the presence of the caudal-type homeobox transcription factor 2 (CDX2), a protein critical in intestinal development and differentiation. CDX2 is a nuclear transcription factor expressed in epithelial cells of the intestinal tract, where it regulates genes involved in cell proliferation, adhesion, and polarity. It plays a key role in maintaining intestinal identity by suppressing gastric and squamous differentiation pathways.
In diagnostic applications, CDX2 antibodies are widely employed via immunohistochemistry (IHC) to identify tumors of intestinal origin. CDX2 positivity is a hallmark of colorectal adenocarcinomas, helping distinguish them from other malignancies, such as gastric or ovarian cancers. It is also used to evaluate metastatic carcinomas of unknown primary origin, as CDX2 expression often indicates gastrointestinal tract involvement. However, its expression can occasionally be observed in non-intestinal tumors (e.g., bladder or ovarian mucinous tumors), necessitating contextual interpretation.
Research-wise, CDX2 antibodies aid in studying gut development, homeostasis, and carcinogenesis. Loss of CDX2 expression correlates with poor differentiation and aggressive behavior in colorectal cancers, highlighting its prognostic relevance. Additionally, CDX2 is investigated in Barrett’s esophagus and intestinal metaplasia of the stomach, conditions linked to cancer risk. Overall, CDX2 antibodies serve as both a diagnostic marker and a research tool to explore intestinal biology and disease mechanisms.
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