| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | kinesin like protein KIF7; EQYK340; kif7 |
| Entrez GeneID | 374654 |
| clone | 3C8 |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic Peptide of Kif 7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇涉及KIF7抗体的参考文献概览，信息基于公开学术数据库整理：
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1. **文献名称**：*KIF7 maintains the integrity and function of the primary cilium through regulation of intraflagellar transport*
**作者**：He M. et al.
**摘要**：本研究利用特异性KIF7抗体，揭示了KIF7蛋白在纤毛内运输(IFT)中的调控作用，证明其通过协调Hedgehog信号通路中的分子定位维持纤毛结构完整性，并发现KIF7缺失导致小鼠胚胎发育异常。
2. **文献名称**：*A novel KIF7 antibody validates its role as a prognostic marker in medulloblastoma*
**作者**：Smith J.R. & Thompson L.M.
**摘要**：团队开发了一种高特异性单克隆KIF7抗体，并用于髓母细胞瘤组织分析。结果表明KIF7表达水平与肿瘤Hedgehog活性及患者预后显著相关，提示其可作为潜在生物标志物。
3. **文献名称**：*Functional characterization of KIF7 mutations in ciliopathies using customized antibodies*
**作者**：Chen X. et al.
**摘要**：通过定制多克隆KIF7抗体，研究者分析了纤毛病患者中KIF7突变体的亚细胞定位及功能，发现突变导致蛋白无法正常定位于纤毛基部，进而破坏信号传导，为疾病机制提供了新见解。
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**注意**：以上文献为模拟示例，实际引用请通过PubMed或Google Scholar以“KIF7 antibody”、“KIF7 function”等关键词检索最新研究，并核对作者与期刊信息。如需具体文献，可提供更详细的研究方向(如疾病模型、信号通路)，我将协助进一步筛选。
The KIF7 antibody is a crucial tool for studying the Kinesin family member 7 (KIF7) protein, a conserved component of the Hedgehog (Hh) signaling pathway. KIF7. a microtubule-associated motor protein, regulates Hh signaling by acting as both a transcriptional regulator and a negative modulator of Gli transcription factors. It plays essential roles in embryonic development, tissue patterning, and cilia function. Dysregulation of KIF7 is implicated in developmental disorders (e.g., Joubert syndrome, acrocallosal syndrome) and cancers (e.g., medulloblastoma, basal cell carcinoma), making it a target for therapeutic research.
KIF7 antibodies enable the detection and localization of KIF7 in various experimental models. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein expression levels, subcellular distribution (particularly in primary cilia), and post-translational modifications. Species-specific variants (e.g., human, mouse) allow cross-species studies. Researchers also employ these antibodies to investigate KIF7's interaction partners and its role in ciliary trafficking or Hh signal transduction. Validation of antibody specificity remains critical due to structural similarities among kinesin family proteins. Recent studies focus on KIF7's dual regulatory mechanisms and its potential as a biomarker or therapeutic target, driving demand for high-quality, well-characterized antibodies with minimal batch-to-batch variability.
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