Rabbit Monoclonal Phospho-TAOK1/2/3(Ser181/Ser181/Ser177) Antibody

The Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) antibody detects the activated forms of TAOK1. TAOK2. and TAOK3. serine/threonine kinases belonging to the STE20 family. These kinases regulate diverse cellular processes, including stress-activated signaling, cytoskeletal reorganization, apoptosis, and mitosis. Phosphorylation at Ser181 (TAOK1/2) or Ser177 (TAOK3) is associated with kinase activation, likely by disrupting autoinhibitory interactions within their regulatory domains. This phosphorylation event is implicated in responses to cellular stress (e.g., osmotic shock) and signaling pathways such as the p38/MAPK cascade. The antibody is widely used in immunoblotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) to study TAOK kinase activation dynamics under conditions like DNA damage, metabolic stress, or cytoskeletal disruption. TAOK kinases also interact with pathways linked to neurodegenerative diseases and cancer, making this antibody a tool for exploring their roles in disease models. Specificity for the phosphorylated forms allows researchers to distinguish active TAOK isoforms from their inactive states, aiding in mechanistic studies of kinase regulation and downstream effectors.