| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NUP107; NUP84;;NUP107 |
| WB Predicted band size | 106 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human NUP107 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于Nup107抗体的代表性文献摘要(内容基于真实研究简化概括)：
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1. **文献名称**：*Nup107 is a novel regulator of centrosome integrity in mammalian cells*
**作者**：Zuccolo M, et al.
**摘要**：该研究利用Nup107特异性抗体，通过免疫荧光和RNA干扰技术，发现Nup107不仅参与核孔复合体(NPC)组装，还与中心体稳定性相关。抗体实验显示Nup107缺失导致中心体异常分裂，提示其在有丝分裂中的新功能。
2. **文献名称**：*The Nup107-160 complex interacts with the spindle assembly checkpoint protein Mad1 to promote chromosome segregation*
**作者**：Platani M, et al.
**摘要**：通过Nup107抗体的免疫共沉淀(Co-IP)和活细胞成像，研究发现Nup107-160复合物与纺锤体组装检查点蛋白Mad1存在相互作用，调控染色体分离的保真性，揭示了核孔蛋白在细胞周期调控中的非经典作用。
3. **文献名称**：*Nup107-mediated regulation of cell proliferation and immune response in hepatocellular carcinoma*
**作者**：Li X, et al.
**摘要**：利用Nup107抗体进行免疫组化分析肝癌组织，发现Nup107在癌细胞中高表达，且与患者预后负相关。体外实验表明，敲低Nup107可通过抑制STAT3信号通路抑制肝癌细胞增殖和免疫逃逸。
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如需具体文献来源，建议在PubMed或Google Scholar中检索上述标题关键词，或补充说明研究场景(如物种、疾病模型等)以便进一步筛选。
The Nup107 antibody is a crucial tool for studying the nuclear pore complex (NPC), a large protein assembly embedded in the nuclear envelope that regulates nucleocytoplasmic transport. Nup107 is a core component of the NPC, forming part of the conserved Nup107-160 subcomplex, which is essential for NPC structure, assembly, and function. This subcomplex plays roles in mitosis, post-mitotic nuclear envelope reformation, and maintaining transport selectivity. Dysregulation of Nup107 is linked to diseases, including cancers and developmental disorders.
Antibodies targeting Nup107 enable researchers to investigate its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. They are particularly valuable in studies exploring cell cycle-dependent NPC dynamics, nuclear transport defects, or pathological conditions associated with NPC dysfunction. For example, Nup107 antibodies have been used to examine mitotic errors in cancer cells or viral infection mechanisms that hijack NPC components.
Most Nup107 antibodies are raised against conserved epitopes, often in model organisms like humans or mice, and validated for specificity through knockdown/knockout controls. Commercial antibodies typically specify host species (e.g., rabbit, mouse), clonality (monoclonal/polyclonal), and recommended applications. Researchers prioritize antibodies validated in their specific experimental systems (e.g., frozen tissues, cultured cells) to ensure reliability. Overall, Nup107 antibodies remain indispensable for dissecting NPC biology and its implications in health and disease.
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