| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Peroxin 11B; PEX11 beta; PEX11B; Pex11p beta; PEX14B;;Peroxin 11B |
| WB Predicted band size | Calculated MW: 28 kDa ; Observed MW: 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Peroxin 11B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于PEX11B抗体的模拟参考文献示例(注：文献为虚拟生成，建议通过学术数据库获取真实文献)：
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1. **文献名称**: *"A monoclonal antibody targeting PEX11B reveals its role in peroxisomal membrane elongation"*
**作者**: Tanaka, K. et al.
**摘要**: 本研究开发了一种特异性识别PEX11B的单克隆抗体，通过免疫荧光和电镜技术证实PEX11B在过氧化物酶体膜延伸中的关键作用，并发现其缺失导致过氧化物酶体形态异常。
2. **文献名称**: *"PEX11B antibody-based profiling identifies peroxisome dysfunction in metabolic syndromes"*
**作者**: Gomez, M. et al.
**摘要**: 利用PEX11B抗体对代谢综合征患者肝脏样本进行分析，发现PEX11B表达下调与过氧化物酶体功能受损、脂质代谢紊乱显著相关，提示其作为潜在治疗靶点。
3. **文献名称**: *"Validation of a commercial PEX11B antibody for immunoblot and immunohistochemistry applications"*
**作者**: Chen, L. et al.
**摘要**: 系统性验证某商业化PEX11B抗体的特异性，证实其在Western blot和免疫组化中的可靠性，为过氧化物酶体研究提供标准化工具。
4. **文献名称**: *"PEX11B interacts with mitochondrial fission factors: Insights from co-immunoprecipitation studies using specific antibodies"*
**作者**: Rossi, F. et al.
**摘要**: 通过PEX11B抗体进行免疫共沉淀实验，发现PEX11B与线粒体分裂蛋白DRP1存在相互作用，提示过氧化物酶体与线粒体动态调控的交叉机制。
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建议通过 **PubMed** 或 **Google Scholar** 以关键词“PEX11B antibody”检索真实文献，或查阅《Biochimica et Biophysica Acta (BBA) - Molecular Cell Research》等期刊获取相关研究。
The PEX11B antibody is a crucial tool for studying peroxisome dynamics and associated disorders. PEX11B (Peroxisomal Biogenesis Factor 11 Beta) is a membrane protein essential for peroxisome proliferation, fission, and maintenance. It belongs to the PEX11 family (PEX11α, β, γ) and plays a key role in shaping peroxisomal membranes and regulating their abundance in response to metabolic demands. Dysfunctions in PEX11B are linked to peroxisome biogenesis disorders (PBDs), such as Zellweger spectrum disorders, characterized by neurological impairments and metabolic abnormalities.
Researchers use PEX11B antibodies primarily in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression levels, subcellular localization, and morphological changes in peroxisomes. These studies help elucidate PEX11B's interaction with other peroxins (e.g., PEX19. PEX16) and its role in membrane elongation during peroxisome division. The antibody also aids in investigating disease mechanisms, including lipid metabolism defects and oxidative stress responses. Commercial PEX11B antibodies are typically validated in human, mouse, or rat samples, with specificity confirmed via knockout controls. Recent applications extend to cancer research, as altered peroxisome activity is observed in某些 tumors, highlighting its multifaceted relevance in cell biology and pathology.
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