| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CPN2; ALDOS; CYP11B; CYP11BL; CYPXIB2; P450C18; P-450C18; P450aldo |
| WB Predicted band size | 58 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CYP11B2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇关于TAPP1抗体的示例参考文献(内容为模拟示例，实际文献需通过学术数据库查询)：
---
1. **文献名称**: "TAPP1 interacts with PI3K signaling to modulate T cell activation"
**作者**: Smith A, et al.
**摘要**: 本研究利用TAPP1特异性抗体，通过免疫沉淀和Western blot技术，揭示了TAPP1在Jurkat T细胞中通过结合PI3K下游脂质第二信使PIP3.负向调控T细胞受体(TCR)激活的分子机制。
2. **文献名称**: "Structural analysis of TAPP1 PH domains using monoclonal antibodies"
**作者**: Chen L, et al.
**摘要**: 通过开发高特异性TAPP1单克隆抗体，结合X射线晶体学技术，解析了TAPP1蛋白的PH结构域与PIP3的结合模式，证明其空间构象在细胞膜定位中的关键作用。
3. **文献名称**: "TAPP1 deficiency exacerbates inflammatory responses in macrophages"
**作者**: Kim Y, et al.
**摘要**: 利用TAPP1抗体进行免疫荧光染色，发现TAPP1敲除的巨噬细胞中NF-κB信号通路异常激活，表明TAPP1通过负反馈机制抑制TLR4介导的炎症反应。
---
**备注**：以上文献为示例，实际研究需参考PubMed、Web of Science等平台的最新论文。建议结合具体研究方向(如癌症、免疫、代谢疾病)进一步筛选文献。
The TAPP1 (Tandem PH domain-containing Protein 1) antibody is a tool used to detect and study the TAPP1 protein, which plays a role in phosphoinositide-mediated signaling pathways. TAPP1 contains two pleckstrin homology (PH) domains, with the C-terminal PH domain specifically binding to phosphatidylinositol (3.4)-bisphosphate [PtdIns(3.4)P₂], a lipid secondary messenger involved in membrane trafficking, cell survival, and immune regulation. This interaction localizes TAPP1 to membranes, enabling its regulatory functions. TAPP1 is implicated in modulating pathways downstream of PI3K (phosphoinositide 3-kinase) and Akt, influencing processes like apoptosis, cell proliferation, and immune cell activation. It also interacts with proteins such as PKD1 and PDK1. suggesting roles in stress responses and kinase signaling.
TAPP1 antibodies are critical for investigating its expression, localization, and function in various tissues and disease contexts. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation. Research highlights TAPP1's involvement in cancer, neurodegenerative disorders, and autoimmune diseases, with altered expression observed in tumors and inflammatory conditions. Validated antibodies help elucidate its dual role as a tumor suppressor or promoter, depending on cellular context. Development of TAPP1 antibodies often includes validation via knockout controls to ensure specificity, aiding precise mechanistic studies in both basic and translational research.
×
