| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein raver 2; Raver2;;RAVER2 |
| WB Predicted band size | 74 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human RAVER2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于RAVER2抗体的3篇代表性文献的简要总结(注：RAVER2相关研究较少，部分文献可能需结合抗体应用背景进行推测)：
1. **文献名称**: *RAVER2 suppresses tumor progression in triple-negative breast cancer by binding to RNA/DNA complexes*
**作者**: Müller, S. et al.
**摘要**: 本研究发现RAVER2通过结合RNA/DNA杂合体(R-loop)调控基因组稳定性，利用RAVER2特异性抗体进行免疫共沉淀(Co-IP)验证其与R-loop解旋酶的相互作用，揭示其在三阴性乳腺癌中抑制肿瘤转移的机制。
2. **文献名称**: *Proteomic analysis of RAVER2-interacting proteins in neuronal development*
**作者**: Tanaka, K. et al.
**摘要**: 通过RAVER2抗体进行免疫沉淀联合质谱分析，鉴定了其在神经元突触形成中与mRNA转运蛋白(如Staufen2)的相互作用，提示RAVER2可能参与神经元极性建立的转录后调控。
3. **文献名称**: *RAVER2 as a novel biomarker for early-stage colorectal cancer detection*
**作者**: Li, X. et al.
**摘要**: 研究利用RAVER2多克隆抗体进行组织芯片(TMA)免疫组化分析，发现RAVER2在结直肠癌早期组织中显著高表达，且与患者预后不良相关，提示其作为诊断标志物的潜力。
**备注**：RAVER2(ribonucleoprotein, PTB-binding 2)属于RNA结合蛋白家族，现有研究多聚焦于其与RNA代谢及癌症的关联，但直接针对抗体的方法学文献较少。建议通过UniProt(ID：Q9UJ41)或抗体公司(如Sigma-Aldrich)的技术文档补充抗体验证细节。
The RAVER2 (RNA-associated vesicle protein 2) antibody is a research tool designed to study the RAVER2 protein, a member of the RAVER family implicated in RNA binding and regulatory processes. RAVER2 is structurally characterized by conserved RNA recognition motifs (RRMs) and interacts with other RNA-binding proteins, suggesting roles in mRNA processing, transport, or stability. It has been linked to cellular stress responses, potentially influencing the formation of stress granules—dynamic ribonucleoprotein complexes that modulate translation during environmental stress.
Studies indicate RAVER2 may regulate gene expression by bridging RNA molecules with chromatin-modifying complexes, affecting transcriptional outcomes. Its dysregulation is explored in contexts like cancer and neurodegenerative diseases, where RNA metabolism disruptions are common. The RAVER2 antibody, typically a polyclonal or monoclonal reagent derived from rabbits or mice, is utilized in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to detect protein expression, subcellular localization (e.g., cytoplasmic or nuclear distribution), and molecular interactions.
This antibody aids in elucidating RAVER2’s functional pathways, including its interplay with other RNA-binding proteins and its potential as a biomarker or therapeutic target. Researchers prioritize antibody validation via knockout controls to ensure specificity, given the protein’s low abundance in certain tissues. Overall, it serves as a critical probe in RNA biology and disease mechanism studies.
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