Rabbit Monoclonal CSN8 Antibody

The CSN8 antibody is a research tool designed to target the eighth subunit of the COP9 signalosome (CSN), a highly conserved protein complex involved in diverse cellular processes. The COP9 signalosome, composed of eight subunits (CSN1–CSN8), regulates the ubiquitin-proteasome system by mediating the deneddylation of cullin-RING ubiquitin ligases (CRLs), thereby controlling protein degradation and stability. CSN8 (also known as COP9 signalosome subunit 8) plays a structural and functional role in maintaining CSN complex integrity. It facilitates complex assembly, stabilizes interactions between subunits, and contributes to enzymatic activity. Antibodies against CSN8 are widely used in immunoblotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) to study CSN complex dynamics, protein degradation pathways, and cellular responses to stress or DNA damage. Dysregulation of CSN8 has been linked to pathologies such as cancer, autoimmune disorders, and developmental defects, making its study critical for understanding disease mechanisms. Researchers also employ CSN8 antibodies to explore the complex's role in cell cycle regulation, apoptosis, and signal transduction. Validation of antibody specificity, often via knockout cell lines or siRNA-mediated knockdown, is essential to ensure accurate detection in experimental models.