Rabbit Monoclonal ALDH7A1 Antibody

The ALDH7A1 antibody is a crucial tool for studying the aldehyde dehydrogenase 7 family member A1 (ALDH7A1) enzyme, encoded by the ALDH7A1 gene. This enzyme plays a vital role in lysine catabolism by catalyzing the oxidation of α-aminoadipic semialdehyde (α-AASA) to α-aminoadipic acid, a critical step in the pipecolic acid pathway. ALDH7A1 dysfunction is linked to pyridoxine-dependent epilepsy (PDE), a rare autosomal recessive disorder characterized by seizures resistant to conventional antiepileptics but responsive to pyridoxine (vitamin B6). Research using ALDH7A1 antibodies focuses on detecting protein expression levels, subcellular localization (primarily cytosolic), and mutations in clinical or experimental models. These antibodies are widely applied in techniques like Western blotting, immunohistochemistry, and ELISA to investigate tissue-specific expression patterns, diagnose PDE, or explore ALDH7A1's potential roles in other pathologies, including cancer and oxidative stress-related diseases. Validated antibodies often undergo specificity testing using knockout cell lines or tissues to ensure accurate detection. Additionally, they aid in elucidating molecular mechanisms underlying ALDH7A1-associated metabolic disruptions, paving the way for therapeutic strategies targeting lysine metabolism or vitamin B6 pathways.