| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Farnesyl diphosphate synthase; Fdps; FPP synthase; FPP synthetase; FPPS; FPS; Geranyltranstransferase;;FPS |
| WB Predicted band size | Calculated MW: 48 kDa ; Observed MW: 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human FPS |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下为模拟生成的3篇关于FDPS抗体的参考文献示例(非真实文献，仅供格式参考)：
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1. **标题**：FDPS抗体在乳腺癌组织中的表达及其临床意义
**作者**：Chen L, Wang Y.
**摘要**：本研究通过免疫组化分析FDPS蛋白在乳腺癌组织中的表达，发现FDPS高表达与患者预后不良相关，提示其可能作为潜在治疗靶点及预后标志物。
2. **标题**：靶向FDPS的单克隆抗体抑制前列腺癌细胞增殖的机制研究
**作者**：Smith JR, Tanaka K.
**摘要**：开发抗FDPS单克隆抗体并验证其体外活性，证实其通过阻断甲羟戊酸通路抑制雄激素依赖性前列腺癌细胞生长，为治疗耐药性前列腺癌提供新策略。
3. **标题**：FDPS基因敲除小鼠模型中抗体检测技术的优化与应用
**作者**：Gomez A, et al.
**摘要**：建立高特异性FDPS抗体检测方法，应用于FDPS条件性敲除小鼠模型，揭示FDPS在骨代谢中的调控作用，为骨质疏松研究提供工具支持。
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**注**：以上内容为模拟生成，实际文献需通过PubMed、Google Scholar等平台检索。建议使用关键词“FDPS antibody”“farnesyl diphosphate synthase therapeutic target”查找真实研究。
**Background of FDPS Antibody**
Farnesyl Diphosphate Synthase (FDPS) is a key enzyme in the mevalonate pathway, catalyzing the formation of farnesyl diphosphate (FPP), a precursor for cholesterol synthesis and protein prenylation. FDPS plays a critical role in cellular processes such as membrane integrity, hormone production, and post-translational modification of signaling proteins (e.g., Ras family GTPases). Dysregulation of FDPS is linked to diseases like cancer, osteoporosis, and metabolic disorders, making it a therapeutic target.
FDPS antibodies are essential tools for studying the enzyme's expression, localization, and function in these contexts. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to quantify FDPS levels in tissues or cells, particularly in cancer research where FDPS overexpression is associated with tumor progression and drug resistance. For example, bisphosphonates, which inhibit FDPS, are used to treat bone-related cancers and osteoporosis, and FDPS antibodies help evaluate drug efficacy or resistance mechanisms.
Additionally, FDPS antibodies contribute to understanding metabolic diseases, such as cardiovascular disorders linked to cholesterol imbalance. Their application in preclinical models and clinical samples underscores their importance in both basic research and therapeutic development, offering insights into disease mechanisms and potential biomarkers.
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