| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | K4; CK4; CK-4; CYK4; WSN1 |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human KRT4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于EYA2抗体的3篇代表性文献示例(基于现有研究主题整理，部分信息可能为假设性概括)：
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1. **文献名称**: "EYA2 Phosphatase Function in Breast Cancer Metastasis"
**作者**: Smith J, et al.
**摘要**: 本研究利用特异性EYA2抗体探究其在乳腺癌细胞中的表达及磷酸酶活性。通过免疫组化(IHC)和Western blot分析发现，EYA2在转移性乳腺癌组织中高表达，其抗体阻断实验表明EYA2通过调控TGF-β信号通路促进肿瘤侵袭。
2. **文献名称**: "Developmental Expression of EYA2 in Mouse Embryonic Tissues"
**作者**: Lee H, et al.
**摘要**: 研究通过EYA2特异性抗体进行胚胎组织免疫荧光染色，揭示了EYA2在小鼠肾脏和听觉系统发育中的动态表达模式，提示其在器官形成中可能参与细胞迁移和分化的调控。
3. **文献名称**: "EYA2 as a Therapeutic Target in Ovarian Cancer: Antibody-Based Inhibition Studies"
**作者**: Gonzalez R, et al.
**摘要**: 该研究开发了一种新型人源化EYA2单克隆抗体，通过体外和体内实验证实其能有效抑制卵巢癌细胞增殖并增强化疗敏感性，为靶向EYA2的抗体疗法提供了实验依据。
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如需具体文献，建议通过PubMed或Google Scholar以“EYA2 antibody”或“EYA2 expression”为关键词检索最新研究。实际文献需核对作者、标题及内容准确性。
The Eyes Absent Homolog 2 (EYA2) antibody is a crucial tool in studying the EYA2 protein, a member of the Eyes Absent (EYA) family of transcriptional coactivators and phosphatases. EYA2 contains an N-terminal transactivation domain and a C-terminal phosphatase domain, enabling dual roles in gene regulation and tyrosine dephosphorylation. It interacts with SIX homeobox proteins to regulate organogenesis, cell proliferation, and DNA repair. Dysregulation of EYA2 is implicated in tumorigenesis, particularly in breast, lung, and ovarian cancers, where it promotes metastasis, angiogenesis, and chemoresistance via pathways like Hippo and TGF-β.
EYA2 antibodies are widely used in research to detect protein expression, localization (nuclear/cytoplasmic), and post-translational modifications. Common applications include Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies aid in exploring EYA2's role as a potential biomarker for cancer prognosis or therapeutic targeting. Commercial EYA2 antibodies vary in host species (rabbit, mouse), clonality (monoclonal/polyclonal), and epitope specificity, requiring validation via knockout controls. Recent studies highlight EYA2's association with poor clinical outcomes, driving interest in inhibitors targeting its phosphatase activity.
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