Rabbit Monoclonal SLP2 Antibody

The SLP-2 antibody targets stomatin-like protein 2 (SLP-2), a mitochondrial inner membrane protein implicated in regulating mitochondrial structure, energy metabolism, and apoptosis. SLP-2 is overexpressed in various cancers, including breast, gastric, and hepatocellular carcinomas, where it promotes tumor progression by enhancing mitochondrial function, cell proliferation, and resistance to stress. It interacts with mitochondrial proteins like prohibitin and cardiolipin, influencing membrane organization and respiratory chain activity. Beyond oncology, SLP-2 is studied in neurodegenerative and cardiovascular diseases due to its role in mitochondrial homeostasis. Antibodies against SLP-2 are critical tools for detecting its expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research utilizing these antibodies has highlighted SLP-2's potential as a diagnostic biomarker or therapeutic target, particularly in cancers with mitochondrial dysfunction. However, its regulatory mechanisms and tissue-specific functions remain under investigation, necessitating further studies to clarify its pathophysiological roles. The development and validation of SLP-2 antibodies thus support advancing both basic and translational research in mitochondrial biology and disease. (Approx. 200 words)