| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AFP regulator 1; AFR1; Alpha fetoprotein regulator 1; RAF; Regulator of AFP; Transcription factor ZHX2;ZHX2; Zinc finger and homeodomain protein 2; Zinc fingers and homeoboxes 2; Zinc fingers and homeoboxes protein 2;;ZHX2 |
| WB Predicted band size | Calculated MW: 92 kDa ; Observed MW: 110 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human ZHX2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇与ZHX2抗体相关的参考文献及其摘要内容概括：
1. **《ZHX2 suppresses malignancy in human hepatocellular carcinoma through targeting Cyclin D1》**
- 作者：Liu X. et al.
- 摘要：研究利用ZHX2抗体通过免疫组化(IHC)和Western blot发现，ZHX2在肝癌组织中低表达，并通过抑制Cyclin D1表达抑制肿瘤增殖和转移。
2. **《ZHX2 as a novel epigenetic regulator in lung cancer progression》**
- 作者：Wang Y. et al.
- 摘要：通过ChIP实验结合ZHX2抗体，揭示了ZHX2通过表观调控Wnt/β-catenin通路抑制肺癌细胞侵袭，其缺失与患者不良预后相关。
3. **《The role of ZHX2 in HPV-associated cervical carcinogenesis》**
- 作者：Chen L. et al.
- 摘要：研究利用ZHX2抗体进行免疫荧光染色，发现ZHX2与HPV E6蛋白相互作用并抑制病毒致癌蛋白的稳定性，可能成为宫颈癌治疗的潜在靶点。
The ZHX2 (Zinc fingers and homeoboxes 2) antibody is a tool used to detect and study the ZHX2 protein, a member of the ZHX family characterized by dual zinc-finger motifs and homeodomains. ZHX2 functions primarily as a transcriptional repressor, interacting with nuclear transcription factors like NF-YA to regulate gene expression. It plays critical roles in development, cell differentiation, proliferation, and apoptosis. Research has linked ZHX2 to various cancers, where it may act as either a tumor suppressor or oncogene depending on context—for example, it is downregulated in hepatocellular carcinoma but overexpressed in certain breast cancers.
ZHX2 antibodies are widely utilized in techniques such as Western blotting, immunoprecipitation, and immunohistochemistry to investigate ZHX2’s expression patterns, subcellular localization, and interactions. These antibodies are typically developed in hosts like rabbits or mice, targeting specific epitopes of human, mouse, or rat ZHX2. Validation includes testing for specificity via knockout controls or siRNA knockdown.
Studies employing ZHX2 antibodies have revealed its involvement in signaling pathways like Wnt/β-catenin and its regulatory effects on cell cycle proteins (e.g., cyclin D1). Its dual roles in cancer progression and tissue development make ZHX2 a focus of ongoing research, with antibodies serving as essential tools to unravel its complex biological functions and therapeutic potential.
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