| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BM002; Chromosome 13 open reading frame 20; Ubiquitin-fold modifier 1; UFM1;;UFM1 |
| WB Predicted band size | Calculated MW: 9 kDa ; Observed MW: 10 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human UFM1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于UFM1抗体的3篇文献示例(内容为虚构概括，仅供参考)：
1. **文献名称**：*UFM1 Modification in Endoplasmic Reticulum Stress Response*
**作者**：Li, X. et al.
**摘要**：本研究利用UFM1特异性抗体，揭示了UFM1修饰系统在内质网应激中的关键作用，发现UFM1通过调控IRE1α信号通路维持细胞稳态。
2. **文献名称**：*UFM1 Antibody-Based Detection in Cancer Progression*
**作者**：Wang, Y. et al.
**摘要**：通过开发高灵敏度的UFM1抗体，作者发现UFM1在多种癌症中异常表达，并与肿瘤细胞增殖和化疗耐药性显著相关。
3. **文献名称**：*UFM1 Conjugation in Neurodegenerative Disorders*
**作者**：Smith, J. & Patel, R.
**摘要**：利用免疫共沉淀和UFM1抗体，研究证实UFM1修饰异常与阿尔茨海默病中tau蛋白聚集存在直接关联，为治疗提供了新靶点。
(注：以上文献为示例，实际引用需查询PubMed或学术数据库获取真实研究。)
**Background of UFM1 Antibody**
UFM1 (Ubiquitin-fold modifier 1) is a ubiquitin-like protein involved in a post-translational modification process called UFMylation. Discovered in 2004. UFM1 shares structural similarities with ubiquitin but has distinct features, including a unique C-terminal tail that requires proteolytic processing for activation. The UFM1 system—comprising UFM1. its activating enzyme UBA5. conjugating enzyme UFC1. ligase UFL1. and protease UFSP2—plays critical roles in endoplasmic reticulum (ER) stress response, ribosome biogenesis, DNA repair, and maintaining cellular homeostasis.
UFM1 antibodies are essential tools for studying UFMylation dynamics. They detect UFM1 conjugation to substrate proteins or monitor UFM1 system components in techniques like Western blot, immunofluorescence, and immunoprecipitation. Dysregulation of UFMylation is linked to diseases such as cancer, neurodegenerative disorders, and cardiovascular conditions. For instance, mutations in UFM1 pathway genes are associated with developmental delays and early-onset epilepsy.
Research using UFM1 antibodies has unveiled its interaction with targets like DDRGK1 (UFBP1) and its role in regulating ribosome-associated protein quality control. These studies highlight UFM1's importance in cellular stress adaptation and disease pathogenesis, driving interest in therapeutic targeting of the UFM1 pathway.
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