| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CH4; COPS4; CSN4; DCH4; SGN4;;COPS4 |
| WB Predicted band size | Calculated MW: 46 kDa ; Observed MW: 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human COPS4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于COPS4抗体的3篇虚构参考文献示例(基于常见研究场景模拟，非真实文献)：
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1. **文献名称**: *"COPS4 Stabilizes c-Jun to Promote Lung Adenocarcinoma Metastasis"*
**作者**: Chen, L.; Wang, X.; et al.
**摘要**: 本研究利用COPS4特异性抗体通过免疫组化(IHC)和Western blot技术，发现COPS4在肺癌组织中高表达并与患者生存率负相关。实验表明，COPS4通过结合并稳定转录因子c-Jun蛋白，促进肿瘤侵袭转移，抗体阻断实验进一步验证了其功能依赖性。
2. **文献名称**: *"The Role of COPS4 in DNA Damage Response: Insights from CRISPR-Cas9 Screening"*
**作者**: Müller, R.; Tanaka, K.; et al.
**摘要**: 通过CRISPR筛选结合COPS4抗体的染色质免疫共沉淀(ChIP)分析，作者发现COPS4作为COP9信号体的核心组分，直接参与ATM激酶介导的DNA损伤修复通路。抗体介导的蛋白互作实验揭示了COPS4与BRCA1复合体的相互作用机制。
3. **文献名称**: *"COPS4 Antibody-Based Profiling Identifies Its Oncogenic Role in Glioblastoma"*
**作者**: Gupta, S.; Patel, T.; et al.
**摘要**: 该研究使用COPS4多克隆抗体进行组织微阵列分析，发现COPS4在胶质母细胞瘤中显著上调。功能实验显示，COPS4通过调控EGFR蛋白稳定性促进肿瘤生长，抗体介导的敲低实验证实其对癌细胞增殖的关键作用。
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**注**: 上述文献为示例性质，实际研究中建议通过PubMed或Web of Science检索真实文献(如搜索关键词“COPS4 antibody”或“COPS4 COP9 signalosome”)。真实文献可能涉及COPS4在泛素-蛋白酶体系统、癌症通路或发育生物学中的功能研究。
The COPS4 antibody is a research tool designed to detect and study the COP9 signalosome subunit 4 (COPS4), a key component of the COP9 signalosome (CSN) complex. The CSN is a highly conserved, multi-protein complex involved in regulating diverse cellular processes, including protein degradation, DNA repair, and signal transduction. COPS4. also known as CSN4. plays a structural and functional role in maintaining the integrity of the CSN complex, which interacts with cullin-RING ubiquitin ligases (CRLs) to modulate substrate ubiquitination and proteasomal degradation. Dysregulation of COPS4 has been linked to cancer, developmental disorders, and immune dysfunction, as it influences critical pathways such as cell cycle progression, apoptosis, and stress responses.
COPS4 antibodies are widely used in molecular biology techniques like Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to assess protein expression levels, localization, and interactions in various biological samples. Researchers employ these antibodies to investigate COPS4’s role in diseases, particularly its overexpression in tumors like hepatocellular carcinoma or glioblastoma, where it may promote oncogenic signaling. Additionally, COPS4 antibodies help elucidate mechanisms underlying CSN-mediated regulation of phosphorylation and deneddylation of cullin proteins. Available as monoclonal or polyclonal versions, these antibodies are typically raised in hosts such as rabbits or mice and validated for specificity across human, mouse, and rat models. Their applications span basic research, biomarker discovery, and therapeutic target validation.
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