| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NLTP; SCP2; SCPchi; SCPX;;Sterol carrier protein 2 |
| WB Predicted band size | Calculated MW: 59 kDa ; Observed MW: 58 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Sterol carrier protein 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Sterol Carrier Protein 2(SCP2)抗体的3篇参考文献摘要：
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1. **文献名称**：*"Production and characterization of a monoclonal antibody to sterol carrier protein 2 (SCP2)"*
**作者**：Seedorf U, et al.
**摘要**：该研究报道了一种针对SCP2的单克隆抗体的开发，通过Western blotting和免疫组化验证其特异性，成功用于检测小鼠肝脏组织中SCP2的表达及亚细胞定位。
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2. **文献名称**：*"Immunolocalization of sterol carrier protein-2 in rat tissues: Role in cholesterol trafficking"*
**作者**：Gallegos AM, et al.
**摘要**：利用多克隆SCP2抗体，通过免疫荧光技术揭示了SCP2在大鼠肝脏、肾上腺等组织中的分布，证明其在细胞内胆固醇转运中的关键作用。
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3. **文献名称**：*"Antibody-based profiling of sterol carrier protein 2 (SCP2) in human atherosclerosis"*
**作者**：Yamada S, et al.
**摘要**：研究使用SCP2多克隆抗体分析动脉粥样硬化患者斑块组织，发现SCP2表达水平与胆固醇沉积相关，提示其在病理代谢中的潜在调控机制。
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以上文献均聚焦于SCP2抗体的开发或应用，涵盖蛋白质定位、功能研究及疾病关联分析。如需具体期刊或年份信息，可进一步补充说明。
Sterol carrier protein 2 (SCP2), also known as nonspecific lipid-transfer protein, is a multifunctional protein involved in cholesterol homeostasis, fatty acid metabolism, and intracellular lipid transport. It facilitates the transfer of sterols, phospholipids, and fatty acids between membranes, playing critical roles in lipid biosynthesis, storage, and signaling. SCP2 is highly expressed in tissues with active lipid metabolism, such as the liver, adrenal glands, and brain. Dysregulation of SCP2 has been linked to metabolic disorders, neurodegenerative diseases, and certain cancers, making it a subject of interest in biomedical research.
Antibodies targeting SCP2 are essential tools for studying its expression, localization, and function. These antibodies are typically developed using immunogenic peptides or recombinant SCP2 proteins and validated for specificity through techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). They enable researchers to detect SCP2 in tissue lysates, cell cultures, and pathological specimens. Commercial SCP2 antibodies are often available in polyclonal or monoclonal forms, with applications spanning basic research to clinical diagnostics. For example, they are used to investigate SCP2’s role in atherosclerosis, diabetes, or Alzheimer’s disease by correlating protein levels with disease progression. Proper validation, including knockout cell line controls, is crucial to ensure antibody reliability. SCP2 antibodies contribute significantly to understanding lipid metabolism pathways and developing therapeutic strategies targeting lipid-related disorders.
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