Rabbit Monoclonal UQCRH Antibody

The UQCRH (Ubiquinol-Cytochrome c Reductase Hinge Protein) antibody is a research tool targeting a key subunit of mitochondrial Complex III (cytochrome bc1 complex) in the electron transport chain (ETC). UQCRH, located on the inner mitochondrial membrane, functions as a structural and functional component critical for electron transfer from ubiquinol to cytochrome c, contributing to ATP synthesis. This 14 kDa protein plays a role in stabilizing the dimeric structure of Complex III and modulating its enzymatic activity. Antibodies against UQCRH are widely used in studies investigating mitochondrial dysfunction, metabolic disorders, and diseases linked to oxidative phosphorylation defects, such as neurodegenerative conditions, cancer, and cardiovascular disorders. They enable detection and quantification of UQCRH expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent research highlights UQCRH's potential involvement in apoptosis regulation and its altered expression in certain cancers, positioning it as a biomarker candidate. Validated UQCRH antibodies are essential for exploring mitochondrial dynamics, energy metabolism pathways, and therapeutic targets. Specificity is typically confirmed using knockout controls or siRNA-based validation to ensure accurate interpretation in experimental models.