| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ADH2; Adh4; Alcohol dehydrogenase 4;;ADH4 |
| WB Predicted band size | Calculated MW: 40 kDa ; Observed MW: 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human ADH4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于ADH4抗体的3篇参考文献示例，基于真实或合理推测的研究方向整理而成：
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1. **文献名称**: "Alcohol Dehydrogenase 4 (ADH4) Genetic Variants and Protein Expression in Esophageal Squamous Cell Carcinoma"
**作者**: Li, Y. et al.
**摘要**: 该研究通过免疫组化(使用ADH4特异性抗体)分析ADH4在食管鳞状细胞癌组织中的表达，发现ADH4低表达与肿瘤进展和患者生存率降低相关，提示其可能作为预后标志物。
2. **文献名称**: "Development and Validation of a Novel Monoclonal Antibody for Human ADH4 in Ethanol Metabolism Studies"
**作者**: Smith, J.R. et al.
**摘要**: 研究团队开发了一种高特异性抗ADH4单克隆抗体，并通过Western blot和免疫荧光验证其在人肝组织中的适用性。该抗体被用于探究ADH4在乙醇代谢中的功能及其与酒精性肝病的关联。
3. **文献名称**: "ADH4 Expression in Colorectal Cancer: Correlation with Tumor Stage and Survival Outcomes"
**作者**: García-Sánchez, A. et al.
**摘要**: 利用ADH4抗体对结直肠癌组织进行免疫组化分析，结果显示ADH4在早期癌变中高表达，但在转移性肿瘤中显著下调，提示其可能在肿瘤抑制中发挥作用。
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**说明**：以上文献为示例，实际引用时需通过学术数据库(如PubMed、Web of Science)确认具体文献信息。若需进一步协助查找全文或验证，请提供更多关键词或研究背景。
The ADH4 (Alcohol Dehydrogenase 4) antibody is a tool used to detect and study the ADH4 enzyme, a member of the alcohol dehydrogenase family involved in metabolizing ethanol and other substrates. ADH4. also known as "class II" ADH, is distinct from other ADH isoforms due to its structural variations and substrate preferences. It exhibits high affinity for retinol and medium-chain alcohols, in addition to ethanol, and plays roles in both detoxification and retinoid metabolism. Expressed primarily in the liver, stomach, and gastrointestinal tract, ADH4 is implicated in first-pass ethanol metabolism and protection against dietary toxins.
Research using ADH4 antibodies has explored its tissue-specific expression, evolutionary conservation, and association with diseases. For example, ADH4 gene polymorphisms are linked to alcohol dependence, liver disease, and cancers of the digestive tract. In evolutionary studies, ADH4 variants in primates suggest adaptive changes related to dietary shifts. Antibodies against ADH4 enable techniques like Western blotting, immunohistochemistry, and ELISA to quantify protein levels, assess localization, and investigate its role in metabolic pathways or pathological conditions. These studies contribute to understanding alcohol-related disorders, cancer mechanisms, and the enzyme's broader physiological functions.
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