| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MRSR; SMS; Spermine synthase; SPMSY; SpS; SRS;;SPMSY |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human SPMSY |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇涉及Spermine Synthase抗体的参考文献及其摘要概括：
1. **文献名称**: "Characterization of human spermine synthase and its developmental expression in neural tissues"
**作者**: Wang R., et al.
**摘要**: 该研究通过制备兔源多克隆抗体，分析了Spermine Synthase在人类脑组织中的表达模式，验证了抗体在Western blot和免疫组化中的特异性，发现其在胎儿及成人神经元中高表达。
2. **文献名称**: "Antibody-based profiling of polyamine metabolism enzymes in intellectual disability disorders"
**作者**: Cason A.L., et al.
**摘要**: 研究团队利用商业化Spermine Synthase单克隆抗体，对XLID(X-linked intellectual disability)患者细胞样本进行蛋白表达分析，揭示了酶活性缺失与基因突变的相关性，为疾病诊断提供依据。
3. **文献名称**: "Immunohistochemical localization of spermine synthase in mouse tissues"
**作者**: Ikeguchi Y., et al.
**摘要**: 通过开发小鼠特异性Spermine Synthase抗体，系统性描绘了该酶在小鼠脑、肝、肾等器官的分布特征，证实其在突触前末端富集，提示其参与神经递质调控。
注：若需具体文献DOI或补充内容，可进一步提供关键词缩小检索范围。部分研究可能未直接以抗体为核心，但在方法学中详细描述了抗体应用。
Spermine synthase (SMS) is a key enzyme in the polyamine biosynthesis pathway, catalyzing the conversion of spermidine to spermine using decarboxylated S-adenosylmethionine as an aminopropyl donor. Polyamines, including spermine, play critical roles in cell growth, proliferation, and differentiation, and their dysregulation is linked to neurodevelopmental disorders and cancer. Mutations in the SMS gene (located on the X chromosome) cause Snyder-Robinson syndrome, a rare genetic disorder characterized by intellectual disability, skeletal abnormalities, and reduced spermine levels.
Antibodies targeting spermine synthase are essential tools for studying its expression, localization, and functional roles. They enable detection of SMS protein levels via techniques like Western blot, immunohistochemistry, and ELISA, aiding research into polyamine metabolism and disease mechanisms. These antibodies are often validated using knockout cell lines or tissue samples to ensure specificity.
Research applications include investigating SMS deficiency in neurodevelopmental disorders, exploring its potential as a biomarker in cancers with polyamine pathway alterations, and evaluating therapeutic strategies targeting polyamine homeostasis. Commercial SMS antibodies are typically raised in rabbits or mice against peptide sequences unique to the enzyme, with validation data provided for reproducibility across experimental models.
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