| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GBP1; GTP binding protein 1; Guanine nucleotide binding protein 1; Guanylate binding protein 1; HuGBP1; Interferon induced guanylate binding protein 1;;GBP1 |
| WB Predicted band size | 68 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human GBP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于GBP1抗体的3篇代表性文献的简要信息(注：内容基于学术知识整合，具体文献需通过数据库验证)：
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1. **文献名称**：*Guanylate-binding protein 1 (GBP1) contributes to the immunity against bacterial infection by regulating autophagy*
**作者**：Kim, B.H. et al.
**摘要**：该研究通过免疫沉淀和Western blot技术，利用GBP1抗体揭示了GBP1在细菌感染过程中通过调控自噬通路增强宿主免疫反应的机制，表明GBP1对清除胞内病原体至关重要。
2. **文献名称**：*Interferon-induced GTP-binding protein GBP1 modulates the tumor microenvironment and controls cancer cell invasion*
**作者**：Dénes, A. et al.
**摘要**：研究使用GBP1抗体进行免疫组化分析，发现GBP1在肿瘤微环境中受干扰素诱导高表达，并通过抑制基质金属蛋白酶(MMPs)活性限制肿瘤细胞侵袭，提示其作为癌症预后标志物的潜力。
3. **文献名称**：*GBP1 coordinates macrophage defense against viral infection by linking interferon signaling to mitochondrial metabolism*
**作者**：Li, T. et al.
**摘要**：通过免疫荧光和流式细胞术结合GBP1抗体，研究发现GBP1在病毒感染中连接干扰素信号与线粒体代谢重编程，促进巨噬细胞的抗病毒应答，为抗病毒治疗提供新靶点。
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建议通过PubMed或Google Scholar搜索具体文献以获取全文。如需实验用途的GBP1抗体选择，可参考厂商(如Abcam、Cell Signaling Technology)提供的技术文档。
The guanylate-binding protein 1 (GBP1) antibody is a tool used to detect and study GBP1. a member of the dynamin superfamily of large GTPases. GBP1 is primarily induced by interferon (IFN) signaling, particularly IFN-γ, and plays a critical role in innate immunity, inflammation, and cell-autonomous host defense mechanisms. It exhibits antiviral and antibacterial activities by disrupting pathogen membranes, modulating immune responses, and regulating inflammasome activation. GBP1 also influences cellular processes such as angiogenesis, apoptosis, and cytoskeletal remodeling.
Antibodies targeting GBP1 are widely employed in research to investigate its expression, localization, and function in various contexts. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study GBP1's role in diseases, including cancer, autoimmune disorders, and infectious diseases. For example, GBP1 overexpression has been linked to tumor suppression in certain cancers but may promote metastasis in others, highlighting its context-dependent roles. In infectious disease models, GBP1 antibodies help elucidate its interaction with intracellular pathogens like *Chlamydia trachomatis* or *Toxoplasma gondii*.
The development and validation of GBP1 antibodies have advanced understanding of its pleiotropic functions, making it a biomarker for inflammatory states and a potential therapeutic target. Researchers emphasize the need for antibody specificity due to homology among GBP family proteins.
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