| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SCC; SCCA; SCCA1; SERPINB3; T4A;;Serpin B3 |
| WB Predicted band size | Calculated MW: 45 kDa ; Observed MW: 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Serpin B3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于SerpinB3抗体的3篇参考文献示例(文献为假设性举例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*"SerpinB3 as a biomarker in chronic liver disease"*
**作者**：Catanzaro et al. (2015)
**摘要**：研究通过免疫组化(使用特异性SerpinB3抗体)分析肝硬化患者肝组织，发现SerpinB3表达与纤维化程度正相关，提示其作为疾病进展的潜在标志物。
2. **文献名称**：*"SerpinB3 overexpression in squamous cell carcinoma"*
**作者**：Vidalino et al. (2018)
**摘要**：利用Western blot和ELISA(基于SerpinB3抗体)检测肿瘤样本，发现SerpinB3高表达与癌症侵袭性相关，可能成为治疗靶点。
3. **文献名称**：*"Protease inhibition by SerpinB3: Structural insights and antibody development"*
**作者**：Pontisso et al. (2012)
**摘要**：研究解析SerpinB3抑制蛋白酶的分子机制，并开发单克隆抗体用于体外功能研究，验证其在炎症模型中的调控作用。
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注：以上文献信息为示例，实际引用时需通过PubMed、Web of Science等平台核实具体研究及作者信息。
**Background of SerpinB3 Antibody**
SerpinB3. also known as squamous cell carcinoma antigen 1 (SCCA1), is a member of the serine protease inhibitor (serpin) superfamily. It is encoded by the *SERPINB3* gene and shares structural homology with SerpinB4 (SCCA2). Primarily expressed in epithelial tissues, SerpinB3 regulates proteolytic processes by inhibiting cysteine and serine proteases, including cathepsins and papain-like enzymes. Its physiological role involves maintaining tissue homeostasis and modulating inflammatory responses.
Dysregulation of SerpinB3 is linked to pathological conditions, particularly cancer. Overexpression is observed in various malignancies, such as hepatocellular carcinoma, lung cancer, and squamous cell carcinomas, where it promotes tumor cell survival, proliferation, and resistance to apoptosis. It also contributes to immune evasion and metastasis by interacting with extracellular matrix components and modulating signaling pathways (e.g., TGF-β, NF-κB).
SerpinB3 antibodies are essential tools for detecting and quantifying SerpinB3 in research and diagnostics. They are used in techniques like immunohistochemistry, ELISA, and Western blot to study its expression patterns, localization, and role in disease progression. Clinically, these antibodies aid in identifying SerpinB3 as a potential biomarker for early cancer detection, prognosis, and monitoring therapeutic responses. Additionally, they are explored in developing targeted therapies, such as monoclonal antibodies, to neutralize SerpinB3’s oncogenic functions. Research continues to unravel its complex mechanisms and therapeutic potential in oncology and chronic inflammatory diseases.
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