| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Coiled coil and C2 domain containing 1A; FREUD 1; Freud 1/Aki1; MRT3;;CC2D1A |
| WB Predicted band size | Calculated MW: 104 kDa ; Observed MW: 130 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human CC2D1A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于CC2D1A抗体的3篇参考文献示例(文献信息为虚构，仅作格式示例)：
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1. **文献名称**: *CC2D1A regulates neuronal migration via NF-κB signaling*
**作者**: Smith A, et al.
**摘要**: 本研究利用CC2D1A特异性抗体进行免疫组化和Western blot分析，发现CC2D1A通过调控NF-κB通路影响小鼠大脑皮层神经元的迁移，为智力障碍相关机制提供了新见解。
2. **文献名称**: *Structural and functional analysis of CC2D1A in DNA repair*
**作者**: Chen L, et al.
**摘要**: 通过CC2D1A抗体共沉淀实验，揭示了CC2D1A与ATM激酶的相互作用，证明其在DNA损伤修复中的关键作用，并解析了其C端结构域的功能必要性。
3. **文献名称**: *CC2D1A expression profiling in autism spectrum disorders*
**作者**: Kim Y, et al.
**摘要**: 采用CC2D1A抗体对患者脑组织样本进行定量分析，发现自闭症患者前额叶皮层中CC2D1A蛋白表达显著下调，提示其可能作为潜在生物标志物。
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**说明**：
以上文献为示例，实际研究中建议通过PubMed、Google Scholar等平台以关键词“CC2D1A antibody”或“CC2D1A function”检索最新文章，并关注其抗体应用场景(如WB、IP、IHC等)。真实文献可能涉及以下方向：
- CC2D1A在神经发育或精神疾病中的作用
- 其作为转录因子或信号通路调节分子的机制
- 与罕见病(如常染色体隐性智力障碍)的关联研究
The CC2D1A antibody targets the coiled-coil and C2 domain-containing protein 1A (CC2D1A), a multifunctional protein implicated in neuronal development, transcriptional regulation, and signaling pathways. CC2D1A, encoded by the *CC2D1A* gene located on chromosome 19p13.12. contains conserved domains such as DM14 repeats, a coiled-coil region, and a C2 domain, enabling interactions with proteins like NF-κB and components of the PI3K/Akt pathway. It plays roles in serotonin receptor 5-HT1A signaling, calcium-dependent exocytosis, and centrosome regulation. Mutations in *CC2D1A* are linked to autosomal recessive intellectual disability, autism spectrum disorders, and nonsyndromic neurodevelopmental conditions, highlighting its importance in brain function.
CC2D1A antibodies are widely used in research to study protein expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. They help characterize CC2D1A’s nuclear and cytoplasmic distribution, its role in transcriptional repression, and dysregulation in disease models. Commercial antibodies are typically raised against specific epitopes (e.g., human CC2D1A amino acids 700-800) and validated for specificity across species (human, mouse, rat). Studies employing these antibodies have advanced understanding of CC2D1A’s dual roles in neurodevelopment and cancer, where it may act as a tumor suppressor or promoter depending on cellular context.
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