| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | FMO3; FMOII; TMAU;;FMO3 |
| WB Predicted band size | Calculated MW: 60 kDa ; Observed MW: 56 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human FMO3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于FMO3抗体的3篇参考文献，按文献名称、作者及摘要内容概括整理：
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1. **文献名称**：*"Development and characterization of a monoclonal antibody specific for human flavin-containing monooxygenase 3 (FMO3)"*
**作者**：Zhang J, Cashman JR
**摘要**：本研究开发了一种针对人源FMO3蛋白的单克隆抗体，验证了其在Western blot和免疫组化中的特异性。抗体成功应用于检测肝脏和小肠中FMO3的蛋白表达水平，并揭示了FMO3在不同个体中的表达差异。
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2. **文献名称**：*"Trimethylaminuria-associated mutations in FMO3: analysis of protein stability and antibody-based detection"*
**作者**：Mitchell SC, Smith RL
**摘要**：文章通过构建FMO3基因突变体，利用特异性抗体研究突变对蛋白稳定性的影响，发现部分突变导致FMO3降解加速。该抗体为遗传性三甲胺尿症(trimethylaminuria)的分子诊断提供了工具。
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3. **文献名称**：*"FMO3 antibody-based quantification reveals altered hepatic expression in metabolic disorders"*
**作者**：Koukouritaki SB, Simpson P, et al.
**摘要**：通过FMO3特异性抗体对肥胖和糖尿病模型小鼠的肝脏组织进行分析，发现FMO3表达水平与脂质代谢紊乱相关，提示其在代谢疾病中的潜在调控作用。
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如需具体文献链接或补充更多研究，可进一步提供关键词或研究方向。
The flavin-containing monooxygenase 3 (FMO3) antibody is a research tool designed to detect and quantify the FMO3 enzyme, a critical protein expressed primarily in the liver. FMO3 catalyzes the oxygenation of various xenobiotics, including drugs, dietary compounds, and environmental toxins, facilitating their elimination. Mutations in the *FMO3* gene are linked to trimethylaminuria (TMAU), a metabolic disorder characterized by the inability to break down trimethylamine, leading to a strong body odor. FMO3 antibodies are pivotal in studying enzyme expression, localization, and function in both normal and disease states.
These antibodies, often produced in rabbits or mice, are validated for applications like Western blotting, immunohistochemistry, and ELISA. They enable researchers to investigate FMO3's role in drug metabolism, detoxification pathways, and its association with TMAU. Commercially available FMO3 antibodies are essential for diagnosing genetic variants, screening for TMAU, and exploring therapeutic strategies. Recent studies also explore FMO3's potential involvement in lipid metabolism and cardiovascular diseases, broadening its biomedical relevance. However, challenges remain in ensuring antibody specificity due to homology with other FMO isoforms. Overall, FMO3 antibodies are indispensable for unraveling the enzyme's biological impact and translational applications in precision medicine.
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